Human auditory cortical activation during self-vocalization

Jeremy D W Greenlee; Adam W Jackson; Fangxiang Chen; Charles R Larson; Hiroyuki Oya; Hiroto Kawasaki; Haiming Chen; Matthew A Howard III

doi:10.1371/journal.pone.0014744

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Human auditory cortical activation during self-vocalization

Journal article

Open access

Peer reviewed

Human auditory cortical activation during self-vocalization

Jeremy D W Greenlee, Adam W Jackson, Fangxiang Chen, Charles R Larson, Hiroyuki Oya, Hiroto Kawasaki, Haiming Chen and Matthew A Howard III

PloS one, Vol.6(3), pp.e14744-e14744

03/03/2011

DOI: 10.1371/journal.pone.0014744

PMCID: PMC3048394

PMID: 21390228

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Abstract

During speaking, auditory feedback is used to adjust vocalizations. The brain systems mediating this integrative ability have been investigated using a wide range of experimental strategies. In this report we examined how vocalization alters speech-sound processing within auditory cortex by directly recording evoked responses to vocalizations and playback stimuli using intracranial electrodes implanted in neurosurgery patients. Several new findings resulted from these high-resolution invasive recordings in human subjects. Suppressive effects of vocalization were found to occur only within circumscribed areas of auditory cortex. In addition, at a smaller number of sites, the opposite pattern was seen; cortical responses were enhanced during vocalization. This increase in activity was reflected in high gamma power changes, but was not evident in the averaged evoked potential waveforms. These new findings support forward models for vocal control in which efference copies of premotor cortex activity modulate sub-regions of auditory cortex.

Young Adult

Speech - physiology

Time Factors

Acoustic Stimulation

Auditory Cortex - physiopathology

Humans

Middle Aged

Evoked Potentials, Auditory - physiology

Adult

Female

Male

Details

Title: Subtitle: Human auditory cortical activation during self-vocalization
Creators: Jeremy D W Greenlee - Department of Neurosurgery, University of Iowa, Iowa City, Iowa, United States of America. jeremy-greenlee@uiowa.edu
Adam W Jackson
Fangxiang Chen
Charles R Larson
Hiroyuki Oya
Hiroto Kawasaki
Haiming Chen
Matthew A Howard III
Resource Type: Journal article
Publication Details: PloS one, Vol.6(3), pp.e14744-e14744
DOI: 10.1371/journal.pone.0014744
PMID: 21390228
PMCID: PMC3048394
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Publisher: Public Library of Science; United States
Grant note: R01 DC004290 / NIDCD NIH HHS R01DC04290 / NIDCD NIH HHS K23 DC009589 / NIDCD NIH HHS K23DC009589 / NIDCD NIH HHS
Language: English
Date published: 03/03/2011
Academic Unit: Neurology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
Record Identifier: 9984020899302771

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