Journal article
Human chorionic gonadotropin-secreting osteosarcoma
BMJ case reports, Vol.18(1), e261810
01/14/2025
DOI: 10.1136/bcr-2024-261810
PMID: 39809482
Abstract
Secretion of beta human chorionic gonadotropin (β-hCG) is a rare, recently recognised paraneoplastic syndrome. Herein, we present a case of a woman in her 30s with right femur conventional high-grade osteosarcoma and a positive screening urine pregnancy test. Subsequent workup failed to reveal an intrauterine or extrauterine pregnancy. Rather, pathology and gene expression studies confirmed serum β-hCG production by osteosarcoma cells. Though the prognostic implications of β-hCG expression are unclear, β-hCG may be a useful surveillance marker to monitor disease progression or recurrence.
Details
- Title: Subtitle
- Human chorionic gonadotropin-secreting osteosarcoma
- Creators
- Natalia Gabriela Sanchez - University of California, San FranciscoAndrew E Horvai - University of California, San FranciscoEmanuela Zacco - UCSF Helen Diller Family Comprehensive Cancer CenterVarun Monga - University of California, San Francisco
- Resource Type
- Journal article
- Publication Details
- BMJ case reports, Vol.18(1), e261810
- Publisher
- BMJ Publishing Group Ltd
- DOI
- 10.1136/bcr-2024-261810
- PMID
- 39809482
- ISSN
- 1757-790X
- eISSN
- 1757-790X
- Grant note
- P30CA082103 / NIH
- Language
- English
- Date published
- 01/14/2025
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984774250702771
Metrics
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