Human gut microbial degradation of flavonoids : Structure-function relationships

Andrean L SIMONS; Mathieu RENOUF; Suzanne HENDRICH; Patricia A MURPHY

doi:10.1021/jf0500177

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Human gut microbial degradation of flavonoids : Structure-function relationships

Journal article

Peer reviewed

Human gut microbial degradation of flavonoids : Structure-function relationships

Andrean L SIMONS, Mathieu RENOUF, Suzanne HENDRICH and Patricia A MURPHY

Journal of agricultural and food chemistry, Vol.53(10), pp.4258-4263

2005

DOI: 10.1021/jf0500177

PMID: 15884869

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Abstract

The relationship between chemical structure and gut microbial degradation rates of 14 flavonoids, flavone, apigenin, chrysin, naringenin, kaempferol, genistein, daidzein, daidzin, puerarin, 7,4'-dihydroxyflavone, 6,4'-dihydroxyflavone, 5,4'-dihydroxyflavone, 5,3'-dihydroxyflavone, and 4'-hydroxyflavone, was investigated by anaerobically fermenting the flavonoids with human gut microflora (n = 11 subjects). Degradation rates for the 5,7,4'-trihydroxyl flavonoids, apigenin, genistein, naringenin, and kaempferol, were significantly faster than the other structural motifs. Puerarin was resistant to degradation by the gut microflora. Extensive degradation of flavonoids by gut microflora may result in lower overall bioavailability than those flavonoids that are slowly degraded because rapidly degrading flavonoids are less likely to be absorbed intact.

Fundamental and applied biological sciences. Psychology

Food industries

Biological and medical sciences

Details

Title: Subtitle: Human gut microbial degradation of flavonoids : Structure-function relationships
Creators: Andrean L SIMONS - Department of Food Science and Human Nutrition, Iowa State University, 2312 Food Sciences Building, Ames, Iowa 50011, United States
Mathieu RENOUF - Department of Food Science and Human Nutrition, Iowa State University, 2312 Food Sciences Building, Ames, Iowa 50011, United States
Suzanne HENDRICH - Department of Food Science and Human Nutrition, Iowa State University, 2312 Food Sciences Building, Ames, Iowa 50011, United States
Patricia A MURPHY - Department of Food Science and Human Nutrition, Iowa State University, 2312 Food Sciences Building, Ames, Iowa 50011, United States
Resource Type: Journal article
Publication Details: Journal of agricultural and food chemistry, Vol.53(10), pp.4258-4263
DOI: 10.1021/jf0500177
PMID: 15884869
NLM abbreviation: J Agric Food Chem
ISSN: 0021-8561
eISSN: 1520-5118
Publisher: American Chemical Society; Washington, DC
Language: English
Date published: 2005
Academic Unit: Oral Pathology, Radiology and Medicine; Pathology; Pharmaceutical Sciences and Experimental Therapeutics; Radiation Oncology
Record Identifier: 9984047766602771

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