Journal article
Human immunodeficiency virus (HIV) type 1 infection status and in vitro susceptibility to HIV infection among high-risk HIV-1 : seronegative hemophiliacs
The Journal of infectious diseases, Vol.172(1), pp.228-231
1995
DOI: 10.1093/infdis/172.1.228
PMID: 7797917
Abstract
Blood samples were obtained from 16 hemophiliacs who had a 50%–94% defined risk of human immunodeficiency virus (HIV) type 1 infection on the basis of treatment history and from 14 controls not at risk for HIV infection. HIV-1 was not detected in any of 12 patient samples by cocultivation nor in 14 patient samples by the polymerase chain reaction. Peripheral blood cells from 7 seronegative hemophiliacs at highest risk of seroconversion (94%) were less susceptible to HIV-1 infection in vitro than were cells from healthy controls (P < .025, one-tailed Wilcoxon rank sum test). In contrast, the susceptibility to HIV-1 infection of lymphocytes from 6 seronegative hemophiliacs at moderate risk (50%–56%) of seroconversion did not differ from that of cells from controls or from high-risk hemophiliacs. Therefore, prolonged periods of seronegative HIV-1 infection are not common in this high-risk population. In addition, among hemophiliacs there may exist heterogeneity in susceptibility to HIV-1 infection in vitro and in vivo.
Details
- Title: Subtitle
- Human immunodeficiency virus (HIV) type 1 infection status and in vitro susceptibility to HIV infection among high-risk HIV-1 : seronegative hemophiliacs
- Creators
- J Brooks Jackson - Case Western Reserve univ. school medicine, univ. hosp. Cleveland, Cleveland OH 44106, United StatesMichael M Lederman - Case Western Reserve univ. school medicine, univ. hosp. Cleveland, Cleveland OH 44106, United StatesBarbara L Kroner - Case Western Reserve univ. school medicine, univ. hosp. Cleveland, Cleveland OH 44106, United StatesGilbert C White III - Case Western Reserve univ. school medicine, univ. hosp. Cleveland, Cleveland OH 44106, United StatesM Elaine Eyster - Case Western Reserve univ. school medicine, univ. hosp. Cleveland, Cleveland OH 44106, United StatesLouis M Aledort - Case Western Reserve univ. school medicine, univ. hosp. Cleveland, Cleveland OH 44106, United StatesMargaret W Hilgartner - Case Western Reserve univ. school medicine, univ. hosp. Cleveland, Cleveland OH 44106, United StatesCraig M Kessler - Case Western Reserve univ. school medicine, univ. hosp. Cleveland, Cleveland OH 44106, United StatesAlan R Cohen - Case Western Reserve univ. school medicine, univ. hosp. Cleveland, Cleveland OH 44106, United StatesKevin P Kiger - Case Western Reserve univ. school medicine, univ. hosp. Cleveland, Cleveland OH 44106, United StatesJames J Goedert - Case Western Reserve univ. school medicine, univ. hosp. Cleveland, Cleveland OH 44106, United States
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.172(1), pp.228-231
- Publisher
- University of Chicago Press; Chicago, IL
- DOI
- 10.1093/infdis/172.1.228
- PMID
- 7797917
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Language
- English
- Date published
- 1995
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984047861202771
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