Journal article
Human leukocyte antigen class I and class II genes polymorphisms might be associated with interferon alpha therapy efficiency of chronic hepatitis B
Antiviral research, Vol.89(3), pp.189-192
03/01/2011
DOI: 10.1016/j.antiviral.2011.01.001
PMID: 21241740
Abstract
Certain host genetic polymorphisms in human leukocyte antigen (HLA) genes are reported to be associated with response to interferon alpha (IFN alpha) therapy. Two hundred and eighteen IFN alpha treatment-naive chronic hepatitis B (CHB) patients were enrolled in the present study. HLA-A. B. C and DQA1, DQB1. DRB1 gene alleles were detected by polymerase chain reaction-sequencing based typing (PCR-SBT) and PCR-sequence specific primer (PCR-SSP). respectively. Frequencies of HLA-DQB1*0303 and DRB1*08 in response group were clearly lower than those in nonresponse group (P = 0.019. OR = 1.81, 95% CI = 1.07-3.15: P = 0.031, OR = 2.43, 95% CI = 1.02-5.98, respectively). Frequencies of haplotype *1101-*4601-*0102 (HIA-A, B. C) and haplotype *0302-*0303-*09 (HIA-DQA1, DQB1, DRB1) were clearly lower than those in nonresponse group (P = 0.009, OR = 4.84, 95% CI = 1.29-19.48; P = 0.031, OR = 1.94, 95% CI = 1.01-3.73. respectively). These results suggest that patients with HLA-DQB1*0303 or DRB1*08 alleles, and haplotype *1101-*4601-*0102 (HLA-A, B, C) or haplotype *0302-*0303-*09 (HLA-DQA1, DQB1, DRB1). might be less responsive to IFN alpha treatment. (C) 2011 Elsevier B.V. All rights reserved.
Details
- Title: Subtitle
- Human leukocyte antigen class I and class II genes polymorphisms might be associated with interferon alpha therapy efficiency of chronic hepatitis B
- Creators
- Xilin Zhu - Chinese Academy of Medical Sciences & Peking Union Medical CollegeTe Du - Chinese Acad Med Sci, Sch Basic Med, Peking Union Med Coll, Natl Lab Med Mol Biol,Inst Basic Med Sci, Beijing 100005, Peoples R ChinaXiaopan Wu - Chinese Acad Med Sci, Sch Basic Med, Peking Union Med Coll, Natl Lab Med Mol Biol,Inst Basic Med Sci, Beijing 100005, Peoples R ChinaXinhui GuoNifang Niu - Chinese Academy of Medical Sciences & Peking Union Medical CollegeLiping Pan - Chinese Academy of Medical Sciences & Peking Union Medical CollegeZhenhui Xin - Chinese Acad Med Sci, Sch Basic Med, Peking Union Med Coll, Natl Lab Med Mol Biol,Inst Basic Med Sci, Beijing 100005, Peoples R ChinaLi Wang - Chinese Academy of Medical Sciences & Peking Union Medical CollegeZhuo Li - Capital Medical UniversityHui Li - Chinese Academy of Medical Sciences & Peking Union Medical CollegeYing Liu - Chinese Academy of Medical Sciences & Peking Union Medical College
- Resource Type
- Journal article
- Publication Details
- Antiviral research, Vol.89(3), pp.189-192
- Publisher
- Elsevier
- DOI
- 10.1016/j.antiviral.2011.01.001
- PMID
- 21241740
- ISSN
- 0166-3542
- eISSN
- 1872-9096
- Number of pages
- 4
- Grant note
- 2007CB512806 / National Basic Research Program of China (973 Program); National Basic Research Program of China 2006AA02A410 / National High Technology Research and Development Program of China (863 Program); National High Technology Research and Development Program of China H020920020590 / Beijing Municipal Government Commission for Science Technology 30721063 / Science Fund for Creative Research Groups
- Language
- English
- Date published
- 03/01/2011
- Academic Unit
- Stead Family Department of Pediatrics; Medical Genetics and Genomics
- Record Identifier
- 9984701550602771
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