Journal article
Human neutrophils is not equal to murine neutrophils: Does it matter?
Immunological reviews, Vol.314(1), pp.442-456
03/2023
DOI: 10.1111/imr.13154
PMCID: PMC10049967
PMID: 36380497
Appears in UI Libraries Support Open Access
Abstract
Human and murine neutrophils differ with respect to representation in blood, receptors, nuclear morphology, signaling pathways, granule proteins, NADPH oxidase regulation, magnitude of oxidant and hypochlorous acid production, and their repertoire of secreted molecules. These differences often matter and can undermine extrapolations from murine studies to clinical care, as illustrated by several failed therapeutic interventions based on mouse models. Likewise, coevolution of host and pathogen undercuts fidelity of murine models of neutrophil-predominant human infections. However, murine systems that accurately model the human condition can yield insights into human biology difficult to obtain otherwise. The challenge for investigators who employ murine systems is to distinguish models from pretenders and to know when the mouse provides biologically accurate insights. Testing with human neutrophils observations made in murine systems would provide a safeguard but is not always possible. At a minimum, studies that use exclusively murine neutrophils should have accurate titles supported by data and restrict conclusions to murine neutrophils and not encompass all neutrophils. For now, the integration of evidence from studies of neutrophil biology performed using valid murine models coupled with testing in vitro of human neutrophils combines the best of both approaches to elucidate the mysteries of human neutrophil biology.
Details
- Title: Subtitle
- Human neutrophils is not equal to murine neutrophils: Does it matter?
- Creators
- William M. Nauseef - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Immunological reviews, Vol.314(1), pp.442-456
- DOI
- 10.1111/imr.13154
- PMID
- 36380497
- PMCID
- PMC10049967
- NLM abbreviation
- Immunol Rev
- ISSN
- 0105-2896
- eISSN
- 1600-065X
- Publisher
- Wiley
- Number of pages
- 15
- Grant note
- AI132335 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Electronic publication date
- 11/15/2022
- Date published
- 03/2023
- Academic Unit
- Infectious Diseases; Internal Medicine
- Record Identifier
- 9984323232602771
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