Journal article
Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide
International journal of cancer, Vol.136(1), pp.98-107
01/01/2015
DOI: 10.1002/ijc.28963
PMCID: PMC4270372
PMID: 24817381
Abstract
Knowledge about human papillomaviruses (HPV) types involved in anal cancers in some world regions is scanty. Here, we describe the HPV DNA prevalence and type distribution in a series of invasive anal cancers and anal intraepithelial neoplasias (AIN) grades 2/3 from 24 countries. We analyzed 43 AIN 2/3 cases and 496 anal cancers diagnosed from 1986 to 2011. After histopathological evaluation of formalin-fixed paraffin-embedded samples, HPV DNA detection and genotyping was performed using SPF-10/DEIA/LiPA25 system (version 1). A subset of 116 cancers was further tested for p16(INK4a) expression, a cellular surrogate marker for HPV-associated transformation. Prevalence ratios were estimated using multivariate Poisson regression with robust variance in the anal cancer data set. HPV DNA was detected in 88.3% of anal cancers (95% confidence interval [CI]: 85.1-91.0%) and in 95.3% of AIN 2/3 (95% CI: 84.2-99.4%). Among cancers, the highest prevalence was observed in warty-basaloid subtype of squamous cell carcinomas, in younger patients and in North American geographical region. There were no statistically significant differences in prevalence by gender. HPV16 was the most frequent HPV type detected in both cancers (80.7%) and AIN 2/3 lesions (75.4%). HPV18 was the second most common type in invasive cancers (3.6%). p16(INK4a) overexpression was found in 95% of HPV DNA-positive anal cancers. In view of the results of HPV DNA and high proportion of p16(INK4a) overexpression, infection by HPV is most likely to be a necessary cause for anal cancers in both men and women. The large contribution of HPV16 reinforces the potential impact of HPV vaccines in the prevention of these lesions.
Details
- Title: Subtitle
- Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide
- Creators
- Laia Alemany - Unit of Infections and Cancer, Cancer Epidemiology Research Program, Institut Català d'Oncologia, Barcelona, Spain; CIBER en Epidemiología y Salud Pública (CIBERESP), SpainMaëlle SaunierIsabel Alvarado-CabreroBeatriz QuirósJorge SalmeronHai-Rim ShinEdyta C PirogNúria GuimeràGustavo Hernandez-SuarezAna FelixOmar ClaveroBelen LloverasElena KasamatsuMarc T GoodmanBrenda Y HernandezJan LacoLeopoldo TinocoDaan T GeraetsCharles F LynchVaclav MandysMario PoljakRobert JachJosep VergeChristine ClavelCathy NdiayeJoEllen KlaustermeierAntonio CubillaXavier CastellsaguéIgnacio G BravoMichael PawlitaWilliam G QuintNubia MuñozFrancesc X BoschSilvia de SanjoséHPV VVAP Study Group
- Resource Type
- Journal article
- Publication Details
- International journal of cancer, Vol.136(1), pp.98-107
- Publisher
- United States
- DOI
- 10.1002/ijc.28963
- PMID
- 24817381
- PMCID
- PMC4270372
- ISSN
- 0020-7136
- eISSN
- 1097-0215
- Grant note
- P30 ES005605 / NIEHS NIH HHS P30 CA086862 / NCI NIH HHS P30 CA071789 / NCI NIH HHS
- Language
- English
- Date published
- 01/01/2015
- Academic Unit
- Epidemiology
- Record Identifier
- 9983996070302771
Metrics
21 Record Views