Human papillomavirus and risk of oral cancer

Elaine M Smith; Henry T Hoffman; Kurt S Summersgill; H Lester Kirchner; Lubomir P Turek; Thomas H Haugen

doi:10.1097/00005537-199807000-00027

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Human papillomavirus and risk of oral cancer

Journal article

Peer reviewed

Human papillomavirus and risk of oral cancer

Elaine M Smith, Henry T Hoffman, Kurt S Summersgill, H Lester Kirchner, Lubomir P Turek and Thomas H Haugen

The Laryngoscope, Vol.108(7), pp.1098-1103

07/1998

DOI: 10.1097/00005537-199807000-00027

PMID: 9665264

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Abstract

Although human papillomavirus (HPV), a sexually transmitted virus, is established as a necessary cause for more than 95% of cervical carcinomas, the association with oral squamous cell carcinoma is less well delineated. The purpose of this study was to determine the frequency and types of HPV in squamous cells of a group of patients with newly diagnosed oral or pharyngeal cancer (n = 93) compared with an age- and gender-frequency-matched control group of patients with no history of oral cancer (n = 205). HPV was evaluated from a mouth rinse collection of cells in the oral cavity and tested by 32P-labeled HPV generic probes and DNA sequencing for HPV types. HPV was identified in 15% of the oral cancer cases but in fewer than 5% of the controls (P < .05). The risk of cancer associated with HPV infection was independent of tobacco and alcohol use (adjusted odds ratio [OR] = 3.70; 95% confidence interval [CI]: 1.47-9.32; P < .05). HPV types included similar and other types not identified previously in the genital tract. There was no statistically significant increased risk of cancer among former tobacco users (former vs. never users: adjusted OR = 0.67, 95% CI: 0.31-1.44, P < .05), but the risk was significantly increased for current users (current vs. never: adjusted OR = 2.63; 95% CI: 1.22-5.71; P < .05). Likewise, former alcohol users were not at increased risk of disease (former vs. never: adjusted OR = 1.78; 95% CI: 0.87-3.67), whereas current alcohol users were (current vs. never: adjusted OR = 2.57; 95% CI: 1.22-5.42; P < .05). HPV-related genital lesions (14.3% vs. 10.6%), oral-genital sexual behavior (42.4% vs. 45.2%), and number (11 or more) of sexual partners (23% v. 17%) were not significantly different between cases and controls. These data suggest that in addition to tobacco and alcohol, HPV plays a role in the development of oral cancer.

Smoking - adverse effects

Multivariate Analysis

Papillomavirus Infections - complications

Prevalence

Carcinoma, Squamous Cell - virology

Humans

Middle Aged

Risk Factors

Male

Pharyngeal Neoplasms - virology

Mouth Neoplasms - virology

Alcohol Drinking - adverse effects

Case-Control Studies

Tumor Virus Infections - complications

Papillomaviridae - classification

Adult

Female

Surveys and Questionnaires

Aged

Odds Ratio

Serotyping

Details

Title: Subtitle: Human papillomavirus and risk of oral cancer
Creators: Elaine M Smith - Department of Preventive Medicine, College of Medicine, University of Iowa, Iowa City 52242, USA
Henry T Hoffman
Kurt S Summersgill
H Lester Kirchner
Lubomir P Turek
Thomas H Haugen
Resource Type: Journal article
Publication Details: The Laryngoscope, Vol.108(7), pp.1098-1103
DOI: 10.1097/00005537-199807000-00027
PMID: 9665264
NLM abbreviation: Laryngoscope
ISSN: 0023-852X
eISSN: 1531-4995
Publisher: United States
Grant note: P60 DC00976-04 / NIDCD NIH HHS P20 15035 04 / PHS HHS R55 DC02285-01 / NIDCD NIH HHS
Language: English
Date published: 07/1998
Academic Unit: Epidemiology; Pathology; Radiation Oncology; Obstetrics and Gynecology; Otolaryngology
Record Identifier: 9984006309702771

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