Journal article
Human papillomavirus infection and survival in oral squamous cell cancer: A population-based study
Otolaryngology-head and neck surgery, Vol.125(1), pp.1-9
07/2001
DOI: 10.1067/mhn.2001.116979
PMID: 11458206
Abstract
Objective: To determine whether human papillomavirus (HPV) type 16 affects survival in oral squamous cell carcinoma.
Study design: Two hundred fifty-four patients diagnosed with primary oral cancer were studied for survival in relation to tumor HPV type 16 status. Kaplan-Meier analysis and Cox proportional hazard models were used to assess survival and estimate hazard ratios adjusted for potential confounders.
Results: HPV type 16 DNA was detected in 15.1% of tumors. HPV 16 positive patients had significantly reduced all-cause mortality (hazard ratio [HR] estimates = 0.34, 95% CI = 0.14, 0.83) and disease-specific mortality (HR = 0.17, 95% CI = 0.04, 0.76) compared with HPV 16 negative patients after adjustment for age, stage, treatment, smoking, alcohol, education, and comorbid disease.
Conclusions: The presence of HPV type 16 DNA is independently associated with a favorable prognosis in patients with oral squamous cell carcinoma.
Clinical significance: Although HPV genotyping is currently not widely available, it may provide important prognostic information.
Details
- Title: Subtitle
- Human papillomavirus infection and survival in oral squamous cell cancer: A population-based study
- Creators
- Seth R. Schwartz - Fred Hutch Cancer CenterBevan Yueh - Fred Hutch Cancer CenterJames K. McDougall - VA Puget Sound Health Care SystemJanet R. Daling - VA Puget Sound Health Care SystemStephen M. Schwartz - University of Washington
- Resource Type
- Journal article
- Publication Details
- Otolaryngology-head and neck surgery, Vol.125(1), pp.1-9
- DOI
- 10.1067/mhn.2001.116979
- PMID
- 11458206
- NLM abbreviation
- Otolaryngol Head Neck Surg
- ISSN
- 0194-5998
- eISSN
- 1097-6817
- Number of pages
- 9
- Grant note
- National Cancer Institute (http://data.elsevier.com/vocabulary/SciValFunders/100000054) R01CA048996 / National Cancer Institute (http://data.elsevier.com/vocabulary/SciValFunders/100000054)
- Language
- English
- Date published
- 07/2001
- Academic Unit
- Otolaryngology
- Record Identifier
- 9984966847602771
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