Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx

Justine M Ritchie; Elaine M Smith; Kurt F Summersgill; Henry T Hoffman; Donghong Wang; Jens P Klussmann; Lubomir P Turek; Thomas H Haugen

doi:10.1002/ijc.10960

Back

Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx

Journal article

Open access

Peer reviewed

Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx

Justine M Ritchie, Elaine M Smith, Kurt F Summersgill, Henry T Hoffman, Donghong Wang, Jens P Klussmann, Lubomir P Turek and Thomas H Haugen

International journal of cancer, Vol.104(3), pp.336-344

04/10/2003

DOI: 10.1002/ijc.10960

PMID: 12569557

Files and links (1)

url

https://doi.org/10.1002/ijc.10960View

Published (Version of record) Open Access

Abstract

Although studies have established human papillomaviruses (HPVs) as a risk factor for oral and oropharyngeal cancer, it is not clear whether viral infection affects survival in head and neck malignancies. This investigation examined the relationship between HPV and survival in carcinomas of the oral cavity and oropharynx. Formalin-fixed, paraffin-embedded tumor specimens from 139 newly diagnosed cases were tested for HPVs by PCR and DNA sequencing. Patient and tumor characteristics were obtained from questionnaires, pathology reports and cancer registries. Odds ratios (ORs) and relative risks (RRs) were based on logistic and Cox regression models, respectively. HPVs were detected in 21% of the tumors; 83% were HPV-16. Greater risk of HPV infection was associated with males (OR = 2.9, 95% CI = 1.0-8.6), a history of oral-genital sex (OR = 4.2, 95% CI = 1.5-11.7), and oropharyngeal tumors (OR = 10.4, 95% CI = 3.5-31.2). As tobacco usage increased, the odds of HPV detection decreased (OR = 0.97/pack-year, 95% CI = 0.96-0.99). HPV infected patients had better overall survival (RR = 0.3, 95% CI = 0.1-0.8) than those with HPV-negative tumors. There was an interaction between gender and HPV for overall (p = 0.05) and disease-specific (p = 0.03) survival that suggested that HPV infected males had better prognosis than HPV-negative males, but this was not the case among females. HPV status was identified as an independent prognostic factor in oral and oropharyngeal cancers. This result appeared to be gender-specific, suggesting the need for further study of the interaction between HPV and gender on survival.

Prevalence

Prognosis

Tumor Virus Infections - virology

Carcinoma, Squamous Cell - virology

Humans

Middle Aged

Oropharyngeal Neoplasms - mortality

DNA, Viral - analysis

Male

Case-Control Studies

Papillomaviridae - genetics

Carcinoma, Squamous Cell - mortality

Aged, 80 and over

Adult

Female

Papillomavirus Infections - virology

Odds Ratio

Risk Factors

Survival Rate

Tumor Virus Infections - mortality

Oropharyngeal Neoplasms - virology

Mouth Neoplasms - virology

Papillomaviridae - isolation & purification

Papillomavirus Infections - mortality

Mouth Neoplasms - mortality

Aged

Neoplasm Staging

Details

Title: Subtitle: Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx
Creators: Justine M Ritchie - Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA 52242, USA. justine-ritchie@uiowa.edu
Elaine M Smith
Kurt F Summersgill
Henry T Hoffman
Donghong Wang
Jens P Klussmann
Lubomir P Turek
Thomas H Haugen
Resource Type: Journal article
Publication Details: International journal of cancer, Vol.104(3), pp.336-344
DOI: 10.1002/ijc.10960
PMID: 12569557
NLM abbreviation: Int J Cancer
ISSN: 0020-7136
eISSN: 1097-0215
Publisher: United States
Grant note: P20 DE15035 04 / NIDCR NIH HHS P60 DC00976-04 / NIDCD NIH HHS R01 DE11979-01 / NIDCR NIH HHS DE13110-035 / NIDCR NIH HHS
Language: English
Date published: 04/10/2003
Academic Unit: Epidemiology; Pathology; Radiation Oncology; Obstetrics and Gynecology; Otolaryngology
Record Identifier: 9984006313702771

Metrics

17 Record Views

316 Times Cited - Web of Science