Human papillomavirus prevalence in oropharyngeal cancer before vaccine introduction, United States

Martin Steinau; Mona Saraiya; Marc T Goodman; Edward S Peters; Meg Watson; Jennifer L Cleveland; Charles F Lynch; Edward J Wilkinson; Brenda Y Hernandez; Glen Copeland; Maria S Saber; Claudia Hopenhayn; Youjie Huang; Wendy Cozen; Christopher Lyu; Elizabeth R Unger; HPV Typing of Cancers Workgroup

doi:10.3201/eid2005.131311

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Human papillomavirus prevalence in oropharyngeal cancer before vaccine introduction, United States

Journal article

Open access

Peer reviewed

Human papillomavirus prevalence in oropharyngeal cancer before vaccine introduction, United States

Martin Steinau, Mona Saraiya, Marc T Goodman, Edward S Peters, Meg Watson, Jennifer L Cleveland, Charles F Lynch, Edward J Wilkinson, Brenda Y Hernandez, Glen Copeland, …

Emerging infectious diseases, Vol.20(5), pp.822-828

05/2014

DOI: 10.3201/eid2005.131311

PMCID: PMC4012803

PMID: 24751181

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Abstract

We conducted a study to determine prevalence of HPV types in oropharyngeal cancers in the United States and establish a prevaccine baseline for monitoring the impact of vaccination. HPV DNA was extracted from tumor tissue samples from patients in whom cancer was diagnosed during 1995-2005. The samples were obtained from cancer registries and Residual Tissue Repository Program sites in the United States. HPV was detected and typed by using PCR reverse line blot assays. Among 557 invasive oropharyngeal squamous cell carcinomas, 72% were positive for HPV and 62% for vaccine types HPV16 or 18. Prevalence of HPV-16/18 was lower in women (53%) than in men (66%), and lower in non-Hispanic Black patients (31%) than in other racial/ethnic groups (68%-80%). Results indicate that vaccines could prevent most oropharyngeal cancers in the United States, but their effect may vary by demographic variables.

Registries

United States - epidemiology

Prevalence

Humans

Middle Aged

Papillomavirus Infections - epidemiology

Alphapapillomavirus - classification

Male

Oropharyngeal Neoplasms - virology

Oropharyngeal Neoplasms - epidemiology

Papillomavirus Infections - prevention & control

Public Health Surveillance

Aged, 80 and over

Adult

Female

Oropharyngeal Neoplasms - prevention & control

Aged

Papillomavirus Vaccines

Details

Title: Subtitle: Human papillomavirus prevalence in oropharyngeal cancer before vaccine introduction, United States
Creators: Martin Steinau
Mona Saraiya
Marc T Goodman
Edward S Peters
Meg Watson
Jennifer L Cleveland
Charles F Lynch
Edward J Wilkinson
Brenda Y Hernandez
Glen Copeland
Maria S Saber
Claudia Hopenhayn
Youjie Huang
Wendy Cozen
Christopher Lyu
Elizabeth R Unger
HPV Typing of Cancers Workgroup
Resource Type: Journal article
Publication Details: Emerging infectious diseases, Vol.20(5), pp.822-828
DOI: 10.3201/eid2005.131311
PMID: 24751181
PMCID: PMC4012803
NLM abbreviation: Emerg Infect Dis
ISSN: 1080-6040
eISSN: 1080-6059
Publisher: United States
Grant note: U58 DP000844 / NCCDPHP CDC HHS U58 DP000812 / NCCDPHP CDC HHS U58 DP000807 / NCCDPHP CDC HHS 1U58DP000807-3 / NCCDPHP CDC HHS P30 CA177558 / NCI NIH HHS U58 DP000810 / NCCDPHP CDC HHS N01PC35143 / NCI NIH HHS N01-PC-2010-00035 / NCI NIH HHS U58 DP000769 / NCCDPHP CDC HHS N01PC35139 / NCI NIH HHS P30 CA086862 / NCI NIH HHS N01PC35137 / NCI NIH HHS
Language: English
Date published: 05/2014
Academic Unit: Epidemiology
Record Identifier: 9983995008802771

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