Journal article
Human γδ T Cells Recognize Alkylamines Derived from Microbes, Edible Plants, and Tea: Implications for Innate Immunity
Immunity (Cambridge, Mass.), Vol.11(1), pp.57-65
1999
DOI: 10.1016/S1074-7613(00)80081-3
Abstract
Approximately 4% of peripheral blood T cells in humans express a T cell receptor with markedly restricted germline gene segment usage (Vγ2Vδ2). Remarkably, these T cells expand 2- to 10-fold (8%–60% of all circulating T cells) during many microbial infections. We show here that these T cells recognize a family of naturally occurring primary alkylamines in a TCR-dependent manner. These antigenic alkylamines are secreted to millimolar concentrations in bacterial supernatants and are found in certain edible plants. Given the large numbers of memory Vγ2Vδ2 T cells in adult humans, recognition of alkylamine antigens offers the immune system a response of the magnitude of major superantigens for αβ T cells and may bridge the gap between innate and adaptive immunity.
Details
- Title: Subtitle
- Human γδ T Cells Recognize Alkylamines Derived from Microbes, Edible Plants, and Tea: Implications for Innate Immunity
- Creators
- Jack F Bukowski - Brigham and Women's HospitalCraig T Morita - University of IowaMichael B Brenner - Brigham and Women's Hospital
- Resource Type
- Journal article
- Publication Details
- Immunity (Cambridge, Mass.), Vol.11(1), pp.57-65
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S1074-7613(00)80081-3
- ISSN
- 1074-7613
- eISSN
- 1097-4180
- Language
- English
- Date published
- 1999
- Academic Unit
- Immunology; Internal Medicine
- Record Identifier
- 9984359931702771
Metrics
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