Journal article
Hundreds of Unrecognized Halogenated Contaminants Discovered in Polar Bear Serum
Angewandte Chemie (International ed.), Vol.57(50), pp.16401-16644
12/10/2018
DOI: 10.1002/anie.201809906
PMCID: PMC6394828
PMID: 30376612
Abstract
Exposure of polar bears (Ursus maritimus) to persistent organic pollutants was discovered in the 1970s, but recent evidence suggests the presence of unknown toxic chemicals in their blood. Protein and phospholipid depleted serum was stirred with polyethersulfone capillaries to extract a broad range of analytes, and nontarget mass spectrometry with "fragmentation flagging" was used for detection. Hundreds of analytes were discovered belonging to 13 classes, including novel polychlorinated biphenyl (PCB) metabolites and many fluorinated or chlorinated substances not previously detected. All analytes were detected in the oldest (mid-1980s) archived polar bear serum from Hudson Bay and Beaufort Sea, and all fluorinated classes showed increasing trends. A mouse experiment confirmed the novel PCB metabolites, suggesting that these could be widespread in mammals. Historical exposure and toxic risk has been underestimated, and these halogenated contaminants pose uncertain risks to this threatened species.
Details
- Title: Subtitle
- Hundreds of Unrecognized Halogenated Contaminants Discovered in Polar Bear Serum
- Creators
- Yanna Liu - Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, T6G 2G3, CanadaEvan S Richardson - Wildlife Research Division, Science and Technology Branch, Environment and Climate Change Canada, Government of Canada, Winnipeg, Manitoba, R3C 4W2, CanadaAndrew E Derocher - Department of Biological Sciences, University of Alberta, Edmonton, Alberta, T6G 2E9, CanadaNicholas J Lunn - Wildlife Research Division, Science and Technology Branch, Environment and Climate Change Canada, Edmonton, Alberta, T6G 2E9, CanadaHans-Joachim Lehmler - Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA, 52242-5000, USAXueshu Li - Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA, 52242-5000, USAYifeng Zhang - Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, T6G 2G3, CanadaJulia Yue Cui - Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, 98105-6099, USALihua Cheng - Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA, 98105-6099, USAJonathan W Martin - Science for Life Laboratory, Department of Environmental Science and Analytical Chemistry, Stockholm University, 10691, Stockholm, Sweden
- Resource Type
- Journal article
- Publication Details
- Angewandte Chemie (International ed.), Vol.57(50), pp.16401-16644
- DOI
- 10.1002/anie.201809906
- PMID
- 30376612
- PMCID
- PMC6394828
- NLM abbreviation
- Angew Chem Weinheim Bergstr Ger
- ISSN
- 0044-8249
- eISSN
- 1521-3773
- Publisher
- Germany
- Grant note
- R01 GM111381 / NIGMS NIH HHS P30 ES005605 / NIEHS NIH HHS ES0007033 / NIH HHS ES013661 / NIH HHS P42 ES013661 / NIEHS NIH HHS R01 ES025708 / NIEHS NIH HHS R21 ES027169 / NIEHS NIH HHS ES019487, ES025708 and GM111381 / NIH HHS ES005605 / NIH HHS R01 ES019487 / NIEHS NIH HHS P30 ES007033 / NIEHS NIH HHS
- Language
- English
- Date published
- 12/10/2018
- Academic Unit
- Occupational and Environmental Health; Iowa Neuroscience Institute; Iowa Superfund Research Program
- Record Identifier
- 9984001079302771
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