Journal article
Hybrid 10 clinical trial: preliminary results
Audiology & neurotology, Vol.14 Suppl 1(1), pp.32-38
2009
DOI: 10.1159/000206493
PMCID: PMC3010181
PMID: 19390173
Abstract
Acoustic plus electric (electric-acoustic) speech processing has been successful in highlighting the important role of articulation information in consonant recognition in those adults that have profound high-frequency hearing loss at frequencies greater than 1500 Hz and less than 60% discrimination scores. Eighty-seven subjects were enrolled in an adult Hybrid multicenter Food and Drug Administration clinical trial. Immediate hearing preservation was accomplished in 85/87 subjects. Over time (3 months to 5 years), some hearing preservation was maintained in 91% of the group. Combined electric-acoustic processing enabled most of this group of volunteers to gain improved speech understanding, compared to their preoperative hearing, with bilateral hearing aids. Most have preservation of low-frequency acoustic hearing within 15 dB of their preoperative pure tone levels. Those with greater losses (>30 dB) also benefited from the combination of electric-acoustic speech processing. Postoperatively, in the electric-acoustic processing condition, loss of low-frequency hearing did not correlate with improvements in speech perception scores in quiet. Sixteen subjects were identified as poor performers in that they did not achieve a significant improvement through electric-acoustic processing. A multiple regression analysis determined that 91% of the variance in the poorly performing group can be explained by the preoperative speech recognition score and duration of deafness. Signal-to-noise ratios for speech understanding in noise improved more than 9 dB in some individuals in the electric-acoustic processing condition. The relation between speech understanding in noise thresholds and residual low-frequency acoustic hearing is significant (r = 0.62; p < 0.05). The data suggest that, in general, the advantages gained for speech recognition in noise by preserving residual hearing exist, unless the hearing loss approaches profound levels. Preservation of residual low-frequency hearing should be considered when expanding candidate selection criteria for standard cochlear implants. Duration of profound high-frequency hearing loss appears to be an important variable when determining selection criteria for the Hybrid implant.
Details
- Title: Subtitle
- Hybrid 10 clinical trial: preliminary results
- Creators
- Bruce J Gantz - Department of Otolaryngology - Head and Neck Surgery, Iowa Cochlear Implant Clinical Research Center, University of Iowa, Iowa City, Iowa 52242-1078, USA. bruce-gantz@uiowa.eduMarlan R HansenChristopher W TurnerJacob J OlesonLina A ReissAaron J Parkinson
- Resource Type
- Journal article
- Publication Details
- Audiology & neurotology, Vol.14 Suppl 1(1), pp.32-38
- DOI
- 10.1159/000206493
- PMID
- 19390173
- PMCID
- PMC3010181
- NLM abbreviation
- Audiol Neurootol
- ISSN
- 1420-3030
- eISSN
- 1421-9700
- Publisher
- Switzerland
- Grant note
- P50 DC000242-24 / NIDCD NIH HHS P50 DC000242 / NIDCD NIH HHS M01 RR000059 / NCRR NIH HHS 2 P50 DC00242 / NIDCD NIH HHS RR00059 / NCRR NIH HHS R01 DC000377 / NIDCD NIH HHS
- Language
- English
- Date published
- 2009
- Academic Unit
- Communication Sciences and Disorders; Molecular Physiology and Biophysics; Biostatistics; Neurosurgery; Otolaryngology
- Record Identifier
- 9983997462102771
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