Hydrochloric acid-induced lung injury: effects of early partial liquid ventilation on survival rate, gas exchange, and pulmonary neutrophil accumulation

Michael A Pakulla; David Seidel; Detlef Obal; Stephan A Loer

doi:10.1007/s00134-004-2419-x

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Hydrochloric acid-induced lung injury: effects of early partial liquid ventilation on survival rate, gas exchange, and pulmonary neutrophil accumulation

Journal article

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Hydrochloric acid-induced lung injury: effects of early partial liquid ventilation on survival rate, gas exchange, and pulmonary neutrophil accumulation

Michael A Pakulla, David Seidel, Detlef Obal and Stephan A Loer

Intensive care medicine, Vol.30(11), pp.2110-2119

11/01/2004

DOI: 10.1007/s00134-004-2419-x

PMID: 15448887

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Abstract

Objective Partial liquid ventilation can improve respiratory functions in acid-induced lung injury. We studied the effects of the interval between induction of injury and initiation of partial liquid ventilation on survival, gas exchange, and pulmonary neutrophil accumulation. Material and methods Anesthetized rats were randomly assigned to one of five groups (n = 6 per group). Group 1 served as the control group, in the other groups an extended lung injury was induced by intratracheal instillation of hydrochloric acid. Whereas lungs of group 2 were gas-ventilated, group 3 received an early partial liquid ventilation (5 min after acid instillation) and group 4 a delayed partial liquid ventilation (30 min after acid instillation, 5 ml/kg perfluorocarbon). Group 5 received an additional continuous perfluorocarbon application of 5 ml·kg-1·h-1 (30 min after acid instillation). Blood gases were measured with an intravascular blood gas sensor. Results Acid instillation resulted in a marked decrease in PO2-values within 30 min (from 481±37 mmHg to 128±71 mmHg, FiO2 1.0). Survival rate of the study period (12 h) was higher with early partial liquid ventilation. We observed no differences between groups in peak PO2-values during treatment. Histopathological examination, however, showed less pulmonary neutrophil accumulation in lungs of the early partial liquid ventilation group when compared to the delayed partial liquid ventilation group. Conclusions Our results suggest that early partial liquid ventilation increases survival after extended acid-induced lung injury. While effects on arterial oxygenation appear not to predict acute survival we observed less intrapulmonary neutrophil accumulation with early partial liquid ventilation.

Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy

Biological and medical sciences

Emergency and intensive respiratory care

Intensive care medicine

Medical sciences

Pneumology

Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases

Details

Title: Subtitle: Hydrochloric acid-induced lung injury: effects of early partial liquid ventilation on survival rate, gas exchange, and pulmonary neutrophil accumulation
Creators: Michael A Pakulla - Heinrich Heine University Düsseldorf
David Seidel - Heinrich Heine University Düsseldorf
Detlef Obal - Heinrich Heine University Düsseldorf
Stephan A Loer - Heinrich Heine University Düsseldorf
Resource Type: Journal article
Publication Details: Intensive care medicine, Vol.30(11), pp.2110-2119
DOI: 10.1007/s00134-004-2419-x
PMID: 15448887
NLM abbreviation: Intensive Care Med
ISSN: 0342-4642
eISSN: 1432-1238
Publisher: Springer
Language: English
Date published: 11/01/2004
Academic Unit: Anesthesia
Record Identifier: 9984696721502771

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