Journal article
Hydrochlorothiazide versus chlorthalidone: evidence supporting their interchangeability
Hypertension (Dallas, Tex. 1979), Vol.43(1), pp.4-9
01/2004
DOI: 10.1161/01.HYP.0000103632.19915.0E
PMID: 14638621
Abstract
Thiazide diuretics are one of the preferred pharmacologic treatments for hypertension. Hydrochlorothiazide and chlorthalidone have been the 2 most commonly used diuretics in major clinical trials. Treatment guidelines and compendia often consider these 2 drugs interchangeable agents within the class of thiazide or thiazide-like diuretics. Many sources list them as equipotent. Despite these beliefs, there is some suggestion that cardiovascular outcomes are not necessarily the same with these 2 drugs. We conducted a literature search from 1960 to 2003 to identify studies that evaluated the pharmacokinetic and blood pressure-lowering effects of these 2 agents. There are significant pharmacokinetic and pharmacodynamic differences between these diuretics. Chlorthalidone is approximately 1.5 to 2.0 times as potent as hydrochlorothiazide, and the former has a much longer duration of action. Whether these pharmacokinetic and pharmacodynamic features cause differences in outcomes is not known.
Details
- Title: Subtitle
- Hydrochlorothiazide versus chlorthalidone: evidence supporting their interchangeability
- Creators
- Barry L Carter - University of IowaMichael E Ernst - Roy J. and Lucille A. Carver College of MedicineJerome D Cohen - Roy J. and Lucille A. Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.43(1), pp.4-9
- DOI
- 10.1161/01.HYP.0000103632.19915.0E
- PMID
- 14638621
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Grant note
- R01HL70740-01A1 / NHLBI NIH HHS R01HL069801-01A1 / NHLBI NIH HHS
- Language
- English
- Date published
- 01/2004
- Academic Unit
- Family and Community Medicine; Pharmacy Practice and Science
- Record Identifier
- 9984297448302771
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