Journal article
Hydrogen Sulfide in Inflammation: A Novel Mediator and Therapeutic Target
Antioxidants & redox signaling, Vol.34(17), pp.1368-1377
06/10/2021
DOI: 10.1089/ars.2020.8211
PMID: 33138636
Abstract
Significance: Inflammation is a normal response to injury, but uncontrolled inflammation can lead to several diseases. In recent years, research has shown endogenously synthesized hydrogen sulfide (H2S) to be a novel mediator of inflammation. This review summarizes the current understanding and recent advances of H2S role with respect to inflammation in different diseases.
Recent Advances: Promising early results from clinical studies suggest an important role of H2S in human inflammatory disease.
Critical Issues: Defining the precise mechanism by which H2S contributes to inflammation is a complex challenge, and there is active ongoing research that is focused on addressing this question. Most of this work has been conducted on animal models of human disease and isolated/cultured cells, and its translation to the clinic is another challenge in the area of H2S research.
Future Directions: Defining the mechanism by which H2S acts as an inflammatory mediator will help us better understand different inflammatory diseases and help develop novel therapeutic approaches for these diseases.
Details
- Title: Subtitle
- Hydrogen Sulfide in Inflammation: A Novel Mediator and Therapeutic Target
- Creators
- Madhav Bhatia - University of OtagoRavinder Reddy Gaddam - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Antioxidants & redox signaling, Vol.34(17), pp.1368-1377
- Publisher
- Mary Ann Liebert, Inc
- DOI
- 10.1089/ars.2020.8211
- PMID
- 33138636
- ISSN
- 1523-0864
- eISSN
- 1557-7716
- Number of pages
- 10
- Grant note
- University of Otago (Vice-Chancellor's Strategic Development Fund) Maurice and Phyllis Paykel Trust
- Language
- English
- Date published
- 06/10/2021
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984446532302771
Metrics
5 Record Views