Journal article
Hydrogen and halogen bonds in drug-drug cocrystals of X-uracil (X = F, I) and lamivudine: extended quadruplex and layered assemblies
Supramolecular chemistry, Vol.33(12), pp.687-692
12/2021
DOI: 10.1080/10610278.2022.2163644
Abstract
We report drug-drug cocrystals of the cytotoxic chemotherapy drugs 5-fluoro (5FU)/iodouracil (5IU) and the antiretroviral lamivudine (3TC). The cocrystal 2(5FU)·(3TC) is sustained by hydrogen bonds to generate a three-dimensional (3D) network while halogen bonds in the cocrystal (5IU)·(3TC) effectively disrupt hydrogen bonds to form layered assemblies.
Details
- Title: Subtitle
- Hydrogen and halogen bonds in drug-drug cocrystals of X-uracil (X = F, I) and lamivudine: extended quadruplex and layered assemblies
- Creators
- Changan Li - University of IowaElizabeth A. Keene - University of IowaCelymar Ortiz-de León - University of IowaLeonard R MacGillivray - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Supramolecular chemistry, Vol.33(12), pp.687-692
- DOI
- 10.1080/10610278.2022.2163644
- ISSN
- 1061-0278
- eISSN
- 1029-0478
- Publisher
- Taylor & Francis
- Grant note
- DOI: 10.13039/100000001, name: NSF, award: DMR-2221086; DOI: 10.13039/100000001, name: NSF, award: DMR-1708673; DOI: 10.13039/100000001, name: National Science Foundation, award: CHE-1828117
- Language
- English
- Electronic publication date
- 01/11/2023
- Date published
- 12/2021
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Chemistry
- Record Identifier
- 9984358260302771
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