Journal article
Hydroxyamphetamine mydriasis in normal subjects
American journal of ophthalmology, Vol.110(1), pp.66-70
07/15/1990
DOI: 10.1016/S0002-9394(14)76940-5
PMID: 2368823
Abstract
Hydroxyamphetamine eyedrops are used to help localize the lesion in Horner's syndrome. Because normal variability in the response to the eyedrops may influence the interpretation of test results in patients with Horner's syndrome, we studied both the interocular variability of the drug's mydriatic effect within each normal subject and the variation between individuals. We used photographs to document the variability among 26 normal subjects. Hydroxyamphetamine hydrobromide 1% eyedrops (Paredrine) were placed in both eyes of normal subjects in the same way that patients with Horner's syndrome are tested. The drug produced a mean increase in pupil size of 1.96 mm (+/- 0.61 S.D.) in the 52 eyes tested. In normal subjects, the mydriatic effect of hydroxyamphetamine was symmetric in each pair of eyes. The mean interocular asymmetry of mydriasis as measured by the difference in dilation (right eye dilation minus left eye dilation) was -0.087 mm (+/- 0.29 S.D.). Thus, the variability of hydroxyamphetamine mydriasis from one eye to the other in a single subject was much lower than the variability between subjects.
Details
- Title: Subtitle
- Hydroxyamphetamine mydriasis in normal subjects
- Creators
- S A Cremer - Department of Ophthalmology, University of Iowa, Iowa CityH S ThompsonK B DigreR H Kardon
- Resource Type
- Journal article
- Publication Details
- American journal of ophthalmology, Vol.110(1), pp.66-70
- DOI
- 10.1016/S0002-9394(14)76940-5
- PMID
- 2368823
- NLM abbreviation
- Am J Ophthalmol
- ISSN
- 0002-9394
- eISSN
- 1879-1891
- Publisher
- United States
- Grant note
- RR59 / NCRR NIH HHS
- Language
- English
- Date published
- 07/15/1990
- Academic Unit
- Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
- Record Identifier
- 9983979934702771
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