Journal article
Hydroxyapatite-Based Magnetic Bionanocomposite as Pharmaceuticals Carriers in Chitosan Scaffolds
Journal of composites science, Vol.5(2), p.37
2021
DOI: 10.3390/jcs5020037
Abstract
Hydroxyapatite (HA) is a bioceramic very similar to the mineral component of bones and teeth. It is well established that osteoblasts grow better onto HA-coated metals than on metals alone. Herein, the preparation of a new system consisting of magnetite (Fe3O4) and HA functionalized with oleic acid and simvastatin (SIMV), and incorporated in chitosan (CHI) scaffolds, was undertaken. HA was synthesized by the hydrothermal method, while Fe3O4 was synthesized by co-precipitation. The polymer matrix was obtained using a 2% CHI solution, and allowed to stir for 2 h. The final material was freeze-dried to produce scaffolds. The magnetic properties remained unchanged after the formation of the composite, as well as after the preparation of the scaffolds, maintaining the superparamagnetism. CHI scaffolds were analyzed by scanning electronic spectroscopy (SEM) and showed a high porosity, with very evident cavities, which provides the functionality of bone growth support during the remineralization process in possible regions affected by bone tissue losses. The synthesized composite showed an average particle size between 15 and 23 nm for particles (HA and Fe3O4). The scaffolds showed considerable porosity, which is important for the performance of various functions of the tissue structure. Moreover, the addition of simvastatin in the system can promote bone formation.
Details
- Title: Subtitle
- Hydroxyapatite-Based Magnetic Bionanocomposite as Pharmaceuticals Carriers in Chitosan Scaffolds
- Creators
- Anderson Valerio Chaves - Univ Fed Ceara, Dept Analyt Chem & Phys Chem, Grp Chem Adv Mat GQMAT, BR-60471970 Fortaleza, CE, BrazilRafael Melo Freire - CEDENNA, Ctr Dev Nanosci & Nanotechnol, Santiago 9170124, ChileVictor Pinheiro Feitosa - Paulo Picanco Sch Dent, BR-06803440 Fortaleza, CE, BrazilNagila Maria Pontes Silva Ricardo - Univ Fed Ceara UFC, Dept Organ & Inorgan Chem, Lab Polymers & Mat Innovat LPIM, BR-60451970 Fortaleza, CE, BrazilJuliano Casagrande Denardin - University of Santiago ChileDavino Machado Andrade Neto - Univ Fed Ceara, Dept Analyt Chem & Phys Chem, Grp Chem Adv Mat GQMAT, BR-60471970 Fortaleza, CE, BrazilPierre Basilio Almeida Fechine - Univ Fed Ceara, Dept Analyt Chem & Phys Chem, Grp Chem Adv Mat GQMAT, BR-60471970 Fortaleza, CE, Brazil
- Resource Type
- Journal article
- Publication Details
- Journal of composites science, Vol.5(2), p.37
- Publisher
- Mdpi
- DOI
- 10.3390/jcs5020037
- ISSN
- 2504-477X
- eISSN
- 2504-477X
- Number of pages
- 13
- Grant note
- PNE-0112-00048.01.00/16 / Funcap; Fundacao Cearense de Apoio ao Desenvolvimento Cientifico e Tecnologico (FUNCAP) AFB180001; FB0807 / Basal CEDENNA 408790/2016-4 / CNPq; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) 001-PROEX 2038.000509/2020-82 / CAPES; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) 1200782; 3170240 / Fondecyt; Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT); CONICYT FONDECYT
- Language
- English
- Date published
- 2021
- Academic Unit
- Operative Dentistry
- Record Identifier
- 9984654467302771
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