Journal article
Hydroxylated polychlorinated biphenyls in human sera from adolescents and their mothers living in two U.S. Midwestern communities
Chemosphere, Vol.147, pp.389-395
03/2016
DOI: 10.1016/j.chemosphere.2015.12.113
PMCID: PMC4747419
PMID: 26774304
Abstract
Hydroxylated polychlorinated biphenyls (OH-PCBs) have been detected in human specimens and some are suspected as being more toxic than their parent compounds. We compared 58 OH-PCB congeners (in 51 chromatographic peaks) in serum samples from participants in the AESOP Study, a longitudinal cohort study of adolescents and their mothers living in urban and rural areas in the United States. We hypothesized that adolescents would have lower levels of OH-PCBs than their mothers and that serum concentration of OH-PCBs would be stable over a 3-year period. We found statistically significant differences in total OH-PCBs between age groups in both East Chicago (p = 0.001) and Columbus Junction (p < 0.001), with adolescents having lower concentrations than their mothers. We observed that lower-chlorinated OH-PCBs were rarely detected, suggesting that they are not retained in serum and/or rapidly biotransformed into other forms. Twelve OH-PCBs, including several that are rarely reported (4,4′-diOH-PCB 202, 4′–OH–PCB 208, and 4-OH-PCB 163) were detected in over 60% of participants. Lastly, from repeated measures within subject serum for three OH-PCBs, concentrations of 4-OH-PCB 107 and 4-OH-PCB 187 changed significantly over three years of the study. •Fifty-eight OH-PCBs were assessed in serum of 85 adolescents and 74 their mothers.•Lower-chlorinated OH-PCBs were rarely detected in serum.•Mothers had significantly higher total OH-PCB concentrations than their children.•4-OH-PCB 107 and 4-OH-PCB 187 changed significantly within subject across 3 years.•OH-PCBs did not differ between subjects from the urban vs. the rural community.
Details
- Title: Subtitle
- Hydroxylated polychlorinated biphenyls in human sera from adolescents and their mothers living in two U.S. Midwestern communities
- Creators
- Wen Xin Koh - Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA 52242, United StatesKeri C Hornbuckle - Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA 52242, United StatesRachel F Marek - Department of Civil and Environmental Engineering, The University of Iowa, Iowa City, IA 52242, United StatesKai Wang - Department of Biostatistics, The University of Iowa, Iowa City, IA 52242, United StatesPeter S Thorne - Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- Chemosphere, Vol.147, pp.389-395
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.chemosphere.2015.12.113
- PMID
- 26774304
- PMCID
- PMC4747419
- ISSN
- 0045-6535
- eISSN
- 1879-1298
- Grant note
- DOI: 10.13039/100000002, name: NIH, award: P42 ES013661, P30 ES005605
- Language
- English
- Date published
- 03/2016
- Academic Unit
- Civil and Environmental Engineering; Occupational and Environmental Health; Biostatistics; IIHR--Hydroscience and Engineering; Iowa Superfund Research Program
- Record Identifier
- 9983806265802771
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