Hymenopsins A and B and a macrophorin analogue from a fungicolous Hymenopsis sp

Lori E Schmidt; Stephen T Deyrup; Jonas Baltrusaitis; Dale C Swenson; Donald T Wicklow; James B Gloer

doi:10.1021/np900613d

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Hymenopsins A and B and a macrophorin analogue from a fungicolous Hymenopsis sp

Journal article

Peer reviewed

Hymenopsins A and B and a macrophorin analogue from a fungicolous Hymenopsis sp

Lori E Schmidt, Stephen T Deyrup, Jonas Baltrusaitis, Dale C Swenson, Donald T Wicklow and James B Gloer

Journal of natural products (Washington, D.C.), Vol.73(3), pp.404-408

03/26/2010

DOI: 10.1021/np900613d

PMCID: PMC2846221

PMID: 19928955

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https://www.ncbi.nlm.nih.gov/pmc/articles/2846221View

Open Access

Abstract

Hymenopsin A (1), hymenopsin B (2), and a new macrophorin analogue, 2',3'-epoxy-13-hydroxy-4'-oxomacrophorin A (3), have been isolated from a fungicolous isolate of Hymenopsis sp. (MYC-1703; NRRL 37638). The structures and relative configurations of these compounds were assigned on the basis of 2D NMR and MS data, and the identity of 1 was confirmed by X-ray crystallographic analysis. The absolute configuration of 2 was proposed on the basis of CD analysis using both empirical and computational methods. Compounds 2 and 3 showed antibacterial activity against Staphylococcus aureus and Bacillus subtilis. Compound 3 was also active against Aspergillus flavus and Fusarium verticillioides.

Sesquiterpenes - isolation & purification

Sesquiterpenes - chemistry

Molecular Conformation

Hawaii

Crystallography, X-Ray

Structure-Activity Relationship

Fungi - chemistry

Microbial Sensitivity Tests

Nuclear Magnetic Resonance, Biomolecular

Molecular Structure

Sesquiterpenes - pharmacology

Staphylococcus aureus - drug effects

Bacillus subtilis - drug effects

Details

Title: Subtitle: Hymenopsins A and B and a macrophorin analogue from a fungicolous Hymenopsis sp
Creators: Lori E Schmidt - Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA
Stephen T Deyrup
Jonas Baltrusaitis
Dale C Swenson
Donald T Wicklow
James B Gloer
Resource Type: Journal article
Publication Details: Journal of natural products (Washington, D.C.), Vol.73(3), pp.404-408
DOI: 10.1021/np900613d
PMID: 19928955
PMCID: PMC2846221
NLM abbreviation: J Nat Prod
ISSN: 0163-3864
eISSN: 1520-6025
Publisher: United States
Grant note: R01 GM060600 / NIGMS NIH HHS R01 GM060600-07 / NIGMS NIH HHS GM 60600 / NIGMS NIH HHS
Language: English
Date published: 03/26/2010
Academic Unit: Chemistry
Record Identifier: 9983985817402771

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