Journal article
Hyperactivity, impulsivity, and inattention in boys with cleft lip and palate: relationship to ventromedial prefrontal cortex morphology
Journal of neurodevelopmental disorders, Vol.2(4), pp.235-242
12/2010
DOI: 10.1007/s11689-010-9060-5
PMCID: PMC3164053
PMID: 22127933
Abstract
The purpose of this study is to evaluate quantitative structural measures of the ventromedial prefrontal cortex (vmPFC) in boys with isolated clefts of the lip and/or palate (ICLP) relative to a comparison group and to associate measures of brain structure with quantitative measures of hyperactivity, impulsivity, and inattentiveness. A total of 50 boys with ICLP were compared to 60 healthy boys without clefts. Magnetic resonance imaging brain scans were used to evaluate vmPFC structure. Parents and teachers provided quantitative measures of hyperactivity, impulsivity, and inattentiveness using the Pediatric Behavior Scale. Boys with ICLP had significantly higher ratings of hyperactivity/impulsivity/inattention (HII) and significantly increased volume of the right vmPFC relative to the comparison group. There was a direct relationship between HII score and vmPFC volume in both the ICLP group and control group, but the relationship was in the opposite direction: in ICLP, the higher the vmPFC volume, the higher the HII score; for the comparison group, the lower the vmPFC volume, the greater the HII score. The vmPFC is a region of the brain that governs behaviors of hyperactivity, impulsivity and inattention (HII). In boys with ICLP, there are higher levels of HII compared to the controls and this is directly related to a significantly enlarged volume of the right vmPFC. Enlargement of this region of the brain is therefore considered to be pathological in the ICLP group and supports the notion that abnormal brain structure (from abnormal brain development) is the underlying etiology for the abnormal behaviors seen in this population.
Details
- Title: Subtitle
- Hyperactivity, impulsivity, and inattention in boys with cleft lip and palate: relationship to ventromedial prefrontal cortex morphology
- Creators
- Peggy Nopoulos - Department of Neurology, University of Iowa, Iowa City, IA USAAaron D Boes - Department of Psychiatry, University of Iowa, Iowa City, IA USAAlthea Jabines - Department of Psychiatry, University of Iowa, Iowa City, IA USAAmy L Conrad - Department of Psychiatry, University of Iowa, Iowa City, IA USAJohn Canady - Department of Otolaryngology, University of Iowa, Iowa City, IA USALynn Richman - Department of Pediatrics, University of Iowa, Iowa City, IA USAJeffrey D Dawson - Department of Biostatistics, University of Iowa, Iowa City, IA USA
- Resource Type
- Journal article
- Publication Details
- Journal of neurodevelopmental disorders, Vol.2(4), pp.235-242
- DOI
- 10.1007/s11689-010-9060-5
- PMID
- 22127933
- PMCID
- PMC3164053
- NLM abbreviation
- J Neurodev Disord
- ISSN
- 1866-1947
- eISSN
- 1866-1955
- Publisher
- Springer US; Boston
- Language
- English
- Date published
- 12/2010
- Academic Unit
- Neurology; Public Health Administration; Psychiatry; Pediatric Psychology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Biostatistics; Craniofacial Anomalies Research Center; Neurology (Pediatrics); Otolaryngology
- Record Identifier
- 9983997459502771
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