Hyperacute transplantation of umbilical cord mesenchymal stromal cells in a model of severe intracerebral hemorrhage

Tanira Giara Mello; Paulo Henrique Rosado-de-Castro; Juliana Ferreira Vasques; Carolina Pinhão; Tayná Monteiro Santos; Renata Rodrigues de Lima; Bernd Uwe Foerster; Fernando Fernandes Paiva; Rosalia Mendez-Otero; Pedro Moreno Pimentel-Coelho

doi:10.2144/fsoa-2021-0121

Back

Hyperacute transplantation of umbilical cord mesenchymal stromal cells in a model of severe intracerebral hemorrhage

Journal article

Open access

Peer reviewed

Hyperacute transplantation of umbilical cord mesenchymal stromal cells in a model of severe intracerebral hemorrhage

Tanira Giara Mello, Paulo Henrique Rosado-de-Castro, Juliana Ferreira Vasques, Carolina Pinhão, Tayná Monteiro Santos, Renata Rodrigues de Lima, Bernd Uwe Foerster, Fernando Fernandes Paiva, Rosalia Mendez-Otero and Pedro Moreno Pimentel-Coelho

Future science OA, Vol.8(4), p.FSO793

04/01/2022

DOI: 10.2144/fsoa-2021-0121

PMID: 35369279

Files and links (1)

url

https://doi.org/10.2144/fsoa-2021-0121View

Published (Version of record) Open Access

Abstract

Hemorrhagic stroke, caused by the leakage of blood from blood vessels to the brain, is a life-threatening condition that reduces the quality of life of a large number of patients worldwide without effective treatments. Here, we induced a severe hemorrhagic stroke in rats to study the effects of a treatment using mesenchymal stromal cells, stem cells obtained from the umbilical cord tissue capable of producing protective molecules for the brain. The treatment; however, did not improve some aspects of the disease, such as the motor ability and the size of the brain lesion, indicating that further studies are still necessary.

Short Communication

Details

Title: Subtitle: Hyperacute transplantation of umbilical cord mesenchymal stromal cells in a model of severe intracerebral hemorrhage
Creators: Tanira Giara Mello - Nuclear Engineering Institute
Paulo Henrique Rosado-de-Castro - Universidade Federal do Rio de Janeiro
Juliana Ferreira Vasques - National Institute of Science and Technology in Regenerative Medicine
Carolina Pinhão - Universidade Federal do Rio de Janeiro
Tayná Monteiro Santos - Universidade Federal do Rio de Janeiro
Renata Rodrigues de Lima - Universidade Federal do Rio de Janeiro
Bernd Uwe Foerster - Universidade de São Paulo
Fernando Fernandes Paiva - Universidade de São Paulo
Rosalia Mendez-Otero - National Institute of Science and Technology in Regenerative Medicine
Pedro Moreno Pimentel-Coelho - National Institute of Science and Technology in Regenerative Medicine
Resource Type: Journal article
Publication Details: Future science OA, Vol.8(4), p.FSO793
DOI: 10.2144/fsoa-2021-0121
PMID: 35369279
NLM abbreviation: Future Sci OA
ISSN: 2056-5623
eISSN: 2056-5623
Publisher: Future Science Ltd
Grant note: E-26/010.002487/2016, Edital 19/2016 / ; PROBITEC 2262/2012 - 23038.004161/2018-88 / ; 88887.199249/2018-00 / ; 402319/2013-3 / ; 88887.136364/2017-00 / ;
Language: English
Date published: 04/01/2022
Academic Unit: Radiology
Record Identifier: 9985143551702771

Metrics

1 Record Views