Hyperglycemia and Cytopenias as Signs of SARS-CoV-2 Delta Variant Infection in Preterm Infants

Timothy J Boly; Melanie E Reyes-Hernandez; Elizabeth C Daniels; Nadine Kibbi; Jennifer R Bermick; Timothy G Elgin

doi:10.1542/peds.2021-055331

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Hyperglycemia and Cytopenias as Signs of SARS-CoV-2 Delta Variant Infection in Preterm Infants

Journal article

Open access

Peer reviewed

Hyperglycemia and Cytopenias as Signs of SARS-CoV-2 Delta Variant Infection in Preterm Infants

Timothy J Boly, Melanie E Reyes-Hernandez, Elizabeth C Daniels, Nadine Kibbi, Jennifer R Bermick and Timothy G Elgin

Pediatrics (Evanston), Vol.149(6), p.1

06/01/2022

DOI: 10.1542/peds.2021-055331

PMCID: PMC10158391

PMID: 35237826

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https://pmc.ncbi.nlm.nih.gov/articles/PMC10158391/pdf/nihms-1893982.pdfView

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Abstract

Information regarding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in premature infants remains limited. Early in the pandemic, several studies reported that the risk of infection in infants was relatively small and that affected infants had a milder disease than what was seen in adults. Since the increase of the delta variant (SARS-CoV-2 B.1.617.2) within the population, there have been increased reports of more severe disease in infants. We present 3 cases of premature, very low birth weight infants with confirmed SARS-CoV-2 infection who presented with significant hyperglycemia and bone marrow dysfunction. Two infants had presumed vertical transmission, and 1 infant was infected by respiratory transmission. Despite the mode of transmission, symptom onset and duration were similar in all infants. All resolved with symptomatic management. In the context of the continuing pandemic, evaluation for SARS-CoV-2 infection should be considered in premature very low birth weight infants who demonstrate certain patterns of acute metabolic and hematologic abnormalities.

Adult

COVID-19 - diagnosis

Female

Humans

Hyperglycemia - diagnosis

Infant

Infant, Newborn

Infant, Premature

Infectious Disease Transmission, Vertical

Leukopenia

Pregnancy

Pregnancy Complications, Infectious - diagnosis

Pregnancy Outcome - epidemiology

Premature Birth - epidemiology

SARS-CoV-2

Thrombocytopenia

Details

Title: Subtitle: Hyperglycemia and Cytopenias as Signs of SARS-CoV-2 Delta Variant Infection in Preterm Infants
Creators: Timothy J Boly - University of Iowa
Melanie E Reyes-Hernandez - University of Iowa
Elizabeth C Daniels - University of Iowa
Nadine Kibbi - University of Iowa
Jennifer R Bermick - University of Iowa
Timothy G Elgin - University of Iowa
Resource Type: Journal article
Publication Details: Pediatrics (Evanston), Vol.149(6), p.1
DOI: 10.1542/peds.2021-055331
PMID: 35237826
PMCID: PMC10158391
NLM abbreviation: Pediatrics
ISSN: 0031-4005
eISSN: 1098-4275
Language: English
Date published: 06/01/2022
Academic Unit: Stead Family Department of Pediatrics; Neonatology
Record Identifier: 9984354049002771

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