Journal article
Hypermethylation of ribosomal DNA in human breast carcinoma
British journal of cancer, Vol.82(3), pp.514-517
02/2000
DOI: 10.1054/bjoc.1999.0955
PMCID: PMC2363317
PMID: 10682657
Abstract
We examined the methylation status of the transcribed domain of ribosomal DNA (rDNA) in 58 patients with breast cancer. The mean percent of methylation was significantly higher in breast tumours than that of normal control samples (
P
< 0.0001). This increased rDNA methylation was associated with oestrogen receptor non-expression (
P
< 0.0273) and with moderately or poorly differentiated tumours as compared to well differentiated tumours (
P
< 0.0475). Our results suggest that rDNA can be a useful marker for monitoring aberrant methylation during breast tumour progression. © 2000 Cancer Research Campaign
Details
- Title: Subtitle
- Hypermethylation of ribosomal DNA in human breast carcinoma
- Creators
- P S Yan - Departments of Pathology and Anatomical Sciences andF J Rodriguez - University of MissouriD E Laux - Departments of Pathology and Anatomical Sciences andM R Perry - Departments of Pathology and Anatomical Sciences andS B Standiford - Departments of Pathology and Anatomical Sciences andT H-M Huang - Departments of Pathology and Anatomical Sciences and
- Resource Type
- Journal article
- Publication Details
- British journal of cancer, Vol.82(3), pp.514-517
- DOI
- 10.1054/bjoc.1999.0955
- PMID
- 10682657
- PMCID
- PMC2363317
- NLM abbreviation
- Br J Cancer
- ISSN
- 0007-0920
- eISSN
- 1532-1827
- Publisher
- Nature Publishing Group
- Language
- English
- Date published
- 02/2000
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984094367502771
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