Hyperpolarized Helium‐3 MRI of exercise‐induced bronchoconstriction during challenge and therapy

Stanley J Kruger; David J Niles; Bernard Dardzinski; Amy Harman; Nizar N Jarjour; Marcella Ruddy; Scott K Nagle; Christopher J Francois; Ronald L Sorkness; Ryan M Burton; Alejandro Munoz del Rio; Sean B Fain

doi:10.1002/jmri.24272

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Hyperpolarized Helium‐3 MRI of exercise‐induced bronchoconstriction during challenge and therapy

Journal article

Peer reviewed

Hyperpolarized Helium‐3 MRI of exercise‐induced bronchoconstriction during challenge and therapy

Stanley J Kruger, David J Niles, Bernard Dardzinski, Amy Harman, Nizar N Jarjour, Marcella Ruddy, Scott K Nagle, Christopher J Francois, Ronald L Sorkness, Ryan M Burton, …

Journal of magnetic resonance imaging, Vol.39(5), pp.1230-1237

05/2014

DOI: 10.1002/jmri.24272

PMCID: PMC3858504

PMID: 24006239

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Abstract

Purpose To investigate the utility of hyperpolarized He‐3 MRI for detecting regional lung ventilated volume (VV) changes in response to exercise challenge and leukotriene inhibitor montelukast, human subjects with exercise induced bronchoconstriction (EIB) were recruited. This condition is described by airway constriction following exercise leading to reduced forced expiratory volume in 1 second (FEV1) coinciding with ventilation defects on hyperpolarized He‐3 MRI. Materials and Methods Thirteen EIB subjects underwent spirometry and He‐3 MRI at baseline, postexercise, and postrecovery at multiple visits. On one visit montelukast was given and on two visits placebo was given. Regional VV was calculated in the apical/basilar dimension, in the anterior/posterior dimension, and for the entire lung volume. The whole lung VV was used as an end‐point and compared with spirometry. Results Postchallenge FEV1 dropped with placebo but not with treatment, while postchallenge VV dropped more with placebo than treatment. Sources of variability for VV included region (anterior/posterior), scan, and treatment. VV correlated with FEV1/ forced vital capacity (FVC) and forced expiratory flow between 25 and 75% of FVC and showed gravitational dependence after exercise challenge. Conclusion A paradigm testing the response of ventilation to montelukast revealed both a whole‐lung and regional response to exercise challenge and therapy in EIB subjects. J. Magn. Reson. Imaging 2014;39:1230–1237. © 2013 Wiley Periodicals, Inc.

exercise

asthma

helium

imaging

therapy

Details

Title: Subtitle: Hyperpolarized Helium‐3 MRI of exercise‐induced bronchoconstriction during challenge and therapy
Creators: Stanley J Kruger - University of Wisconsin
David J Niles - University of Wisconsin
Bernard Dardzinski - Merck Research Laboratories
Amy Harman - Merck Research Laboratories
Nizar N Jarjour - University of Wisconsin
Marcella Ruddy - Merck Research Laboratories
Scott K Nagle - University of Wisconsin
Christopher J Francois - University of Wisconsin
Ronald L Sorkness - University of Wisconsin
Ryan M Burton - University of Wisconsin
Alejandro Munoz del Rio - University of Wisconsin
Sean B Fain - University of Wisconsin
Resource Type: Journal article
Publication Details: Journal of magnetic resonance imaging, Vol.39(5), pp.1230-1237
DOI: 10.1002/jmri.24272
PMID: 24006239
PMCID: PMC3858504
NLM abbreviation: J Magn Reson Imaging
ISSN: 1053-1807
eISSN: 1522-2586
Number of pages: 8
Grant note: National Institutes of Health (NIH/NHLBI) (R01 HL069116)
Language: English
Date published: 05/2014
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Iowa Neuroscience Institute; Health, Sport, and Human Physiology
Record Identifier: 9984051782602771

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