Hyperpolarized helium-3 magnetic resonance lung imaging of non-sedated infants and young children: a proof-of-concept study

Talissa A Altes; Craig H Meyer; Jaime F Mata; Deborah K Froh; Alix Paget-Brown; W. Gerald Teague; Sean B Fain; Eduard E de Lange; Kai Ruppert; Martyn C Botfield; Mac A Johnson; John P Mugler

doi:10.1016/j.clinimag.2017.04.004

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Hyperpolarized helium-3 magnetic resonance lung imaging of non-sedated infants and young children: a proof-of-concept study

Journal article

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Hyperpolarized helium-3 magnetic resonance lung imaging of non-sedated infants and young children: a proof-of-concept study

Talissa A Altes, Craig H Meyer, Jaime F Mata, Deborah K Froh, Alix Paget-Brown, W. Gerald Teague, Sean B Fain, Eduard E de Lange, Kai Ruppert, Martyn C Botfield, …

Clinical imaging, Vol.45, pp.105-110

09/2017

DOI: 10.1016/j.clinimag.2017.04.004

PMID: 28646735

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Abstract

To develop and evaluate a protocol for hyperpolarized helium-3 (HHe) ventilation magnetic resonance imaging (MRI) of the lungs of non-sedated infants and children. HHe ventilation MRI was performed on seven children ≤4years old. Contiguous 2D–spiral helium-3 images were acquired sequentially with a scan time of ≤0.2s/slice. Motion-artifact–free, high signal-to-noise ratio (SNR) images of lung ventilation were obtained. Gas was homogeneously distributed in healthy individuals; focal ventilation defects were found in patients with respiratory diseases. HHe ventilation MRI can aid assessment of pediatric lung disease even at a young age. •High-quality HHe MR images of lungs in nonsedated infants and children are obtained.•A short acquisition time is employed.•Ventilation defects in the lungs of infant with cystic fibrosis (CF) were found.•Changes in lungs detected earlier by MRI than by clinical lung function measures.•HHe MR imaging could be used as an outcome measure in pediatric lung diseases.

Cystic Fibrosis

Magnetic Resonance Imaging

Child

Hyperpolarized helium MRI

Infant

Details

Title: Subtitle: Hyperpolarized helium-3 magnetic resonance lung imaging of non-sedated infants and young children: a proof-of-concept study
Creators: Talissa A Altes - University of Virginia
Craig H Meyer - University of Virginia
Jaime F Mata - University of Virginia
Deborah K Froh - University of Virginia
Alix Paget-Brown - University of Virginia
W. Gerald Teague - University of Virginia
Sean B Fain - University of Wisconsin–Madison
Eduard E de Lange - University of Virginia
Kai Ruppert - University of Pennsylvania
Martyn C Botfield - Vertex Pharmaceuticals (United States)
Mac A Johnson - Vertex Pharmaceuticals (United States)
John P Mugler - University of Virginia
Resource Type: Journal article
Publication Details: Clinical imaging, Vol.45, pp.105-110
DOI: 10.1016/j.clinimag.2017.04.004
PMID: 28646735
NLM abbreviation: Clin Imaging
ISSN: 0899-7071
eISSN: 1873-4499
Publisher: Elsevier Inc
Language: English
Date published: 09/2017
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
Record Identifier: 9984274953302771

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