Journal article
Hypertension: the missing WNKs
American journal of physiology. Renal physiology, Vol.311(1), pp.F16-F27
07/01/2016
DOI: 10.1152/ajprenal.00358.2015
PMCID: PMC4967160
PMID: 27009339
Abstract
The With no Lysine [K] (WNK) family of enzymes are central in the regulation of blood pressure. WNKs have been implicated in hereditary hypertension disorders, mainly through control of the activity and levels of ion cotransporters and channels. Actions of WNKs in the kidney have been heavily investigated, and recent studies have provided insight into not only the regulation of these enzymes but also how mutations in WNKs and their interacting partners contribute to hypertensive disorders. Defining the roles of WNKs in the cardiovascular system will provide clues about additional mechanisms by which WNKs can regulate blood pressure. This review summarizes recent developments in the regulation of the WNK signaling cascade and its role in regulation of blood pressure.
Details
- Title: Subtitle
- Hypertension: the missing WNKs
- Creators
- Hashem A Dbouk - Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas; andChou-Long Huang - Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TexasMelanie H Cobb - Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas; and Melanie.cobb@utsouthwestern.edu
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Renal physiology, Vol.311(1), pp.F16-F27
- DOI
- 10.1152/ajprenal.00358.2015
- PMID
- 27009339
- PMCID
- PMC4967160
- ISSN
- 0363-6127
- eISSN
- 1522-1466
- Grant note
- R01 DK059530 / NIDDK NIH HHS R01 GM053032 / NIGMS NIH HHS
- Language
- English
- Date published
- 07/01/2016
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984094656102771
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