Hypoalgesia induced by microinjection of a norepinephrine antagonist in the raphe magnus: reversal by intrathecal administration of a serotonin antagonist

Donna L Hammond; Richard A Levy; Herbert K Proudfit

doi:10.1016/0006-8993(80)91056-2

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Hypoalgesia induced by microinjection of a norepinephrine antagonist in the raphe magnus: reversal by intrathecal administration of a serotonin antagonist

Journal article

Peer reviewed

Hypoalgesia induced by microinjection of a norepinephrine antagonist in the raphe magnus: reversal by intrathecal administration of a serotonin antagonist

Donna L Hammond, Richard A Levy and Herbert K Proudfit

Brain research, Vol.201(2), pp.475-479

1980

DOI: 10.1016/0006-8993(80)91056-2

PMID: 6893423

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Abstract

Microinjection of phentolamine in the nucleus raphe magnus produces hypoalgesia as assessed by both the tail flick and hot plate tests. The elevation of tail flick latency appears to results from activation of serotonergic raphe-spinal projections, while the elevation of hot plate latency appears to be mediated by activation of non-serotonergic raphe-spinal neurons and/or by activation of raphe neurons which project to supraspinal nuclei.

intrathecal injection

microinjection

nucleus raphe magnus

methysergide

hypoalgesia

phentolamine

Details

Title: Subtitle: Hypoalgesia induced by microinjection of a norepinephrine antagonist in the raphe magnus: reversal by intrathecal administration of a serotonin antagonist
Creators: Donna L Hammond
Richard A Levy
Herbert K Proudfit
Resource Type: Journal article
Publication Details: Brain research, Vol.201(2), pp.475-479
Publisher: Elsevier B.V
DOI: 10.1016/0006-8993(80)91056-2
PMID: 6893423
ISSN: 0006-8993
eISSN: 1872-6240
Language: English
Date published: 1980
Academic Unit: Iowa Neuroscience Institute; Nursing; Anesthesia; Neuroscience and Pharmacology
Record Identifier: 9984006368402771

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