Journal article
Hypofractionated radiotherapy in breast cancer: a 10-year single institution experience
Reports of practical oncology and radiotherapy, Vol.26(6), pp.920-927
01/01/2021
DOI: 10.5603/RPOR.a2021.0109
PMCID: PMC8726432
PMID: 34992864
Abstract
Background: Moderately post-operative hypofractionated radiotherapy (HYPO-RT) for breast cancer is a safe and effective strategy as seen in large prospective trials. This study aimed to assess overall and disease-free survivals, local control, and acute and late toxicities in patients treated with HYPO-RT.
Materials and methods: Data from patients submitted to post-operative HYPO-RT, with or without boost, were evaluated retrospectively. Demographic, disease, and treatment characteristics were collected.
Results: From March 2009 to December 2016, 393 patients were treated. Breast-conserving surgery was performed in 94.7%, immediate reconstruction after mastectomy in 6 (1.5%). Most patients (91.2%) had initial stage (0 to IIA), and chemotherapy was performed in 42.0%, HYPO-RT was mainly performed in 15 or 16 daily fractions of 267 cGy and 265 cGy, respectively. The median follow-up was 5.7 years. There were 25 deaths (6.4%) and 17 (4.3%) local recurrences. At 5 and 10 years, the overall survival, local control, and disease-free survival were, respectively, 96.0% and 79.3%, 99.2% and 94.9%, 96.6%, and 91.9%. Acute grade 3 or 4 dermatitis was observed in 0.9%. Late grade 1 or 2 occurred in less than 3% of the patients.
Conclusion: HYPO-RT is a safe and effective radiotherapy regimen with excellent disease control and overall survival rates, with low acute and late toxicity rates.
Details
- Title: Subtitle
- Hypofractionated radiotherapy in breast cancer: a 10-year single institution experience
- Creators
- Gabriel Faria Najas - Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSilvia Radwanski Stuart - Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloGustavo Nader Marta - Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloLorine Arias Bonifacio Teixeira - Univ Sao Paulo, Fac Med, ICESP, Radiotherapy, Av Dr Arnaldo 251, BR-01246000 Sao Paulo, SP, BrazilVinicius de Carvalho Gico - Univ Sao Paulo, Fac Med, ICESP, Radiotherapy, Av Dr Arnaldo 251, BR-01246000 Sao Paulo, SP, BrazilAlexandre Ruggieri Serante - Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloGeovanne Pedro Mauro - Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloMateus Costa Lima - Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloHeloisa de Andrade Carvalho - Univ Sao Paulo, Fac Med, ICESP, Radiotherapy, Av Dr Arnaldo 251, BR-01246000 Sao Paulo, SP, Brazil
- Resource Type
- Journal article
- Publication Details
- Reports of practical oncology and radiotherapy, Vol.26(6), pp.920-927
- DOI
- 10.5603/RPOR.a2021.0109
- PMID
- 34992864
- PMCID
- PMC8726432
- NLM abbreviation
- Rep Pract Oncol Radiother
- ISSN
- 1507-1367
- eISSN
- 2083-4640
- Publisher
- Via Medica
- Number of pages
- 8
- Language
- English
- Date published
- 01/01/2021
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9984914015002771
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