Hypoglycemia in cystic fibrosis: Prevalence, impact and treatment

Amir Moheet; Christine L. Chan; Andrea Granados; Katie Larson Ode; Antoinette Moran; Alberto Battezzati

doi:10.1016/j.jcf.2019.08.004

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Hypoglycemia in cystic fibrosis: Prevalence, impact and treatment

Journal article

Open access

Peer reviewed

Hypoglycemia in cystic fibrosis: Prevalence, impact and treatment

Amir Moheet, Christine L. Chan, Andrea Granados, Katie Larson Ode, Antoinette Moran and Alberto Battezzati

Journal of cystic fibrosis, Vol.18, pp.S19-S24

10/2019

DOI: 10.1016/j.jcf.2019.08.004

PMID: 31679723

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Abstract

Hypoglycemia is a common and feared complication of insulin therapy. As in type 1 and type 2 diabetes, people with cystic fibrosis related diabetes are also at risk for hypoglycemia related to insulin therapy. Spontaneous hypoglycemia is also common in patients with CF without diabetes, who are not on glucose lowering medications. Spontaneous hypoglycemia in CF may also occur during or after an oral glucose tolerance test. In this review, we will discuss the definition, epidemiology, pathophysiology and impact of hypoglycemia, with a focus on people with cystic fibrosis. We will also review strategies to manage and prevent hypoglycemia. •Patients with CFRD are at risk of hypoglycemia related to insulin therapy.•Post-prandial or reactive hypoglycemia is also common in patients with CF without CFRD.•Prevention of hypoglycemia is a key component of diabetes management.•There are significant knowledge gaps in our understanding of hypoglycemia in CF.

Cystic Fibrosis

CFRD

Hypoglycemia

Reactive hypoglycemia

Details

Title: Subtitle: Hypoglycemia in cystic fibrosis: Prevalence, impact and treatment
Creators: Amir Moheet - University of Minnesota
Christine L. Chan - Children's Hospital Colorado
Andrea Granados - Washington University in St. Louis
Katie Larson Ode - Department of Pediatrics, University of Iowa Stead Family Children's Hospital, Iowa City, IA, USA.
Antoinette Moran - University of Minnesota
Alberto Battezzati - University of Milan
Resource Type: Journal article
Publication Details: Journal of cystic fibrosis, Vol.18, pp.S19-S24
Publisher: Elsevier B.V
DOI: 10.1016/j.jcf.2019.08.004
PMID: 31679723
ISSN: 1569-1993
eISSN: 1873-5010
Grant note: DOI: 10.13039/100000897, name: Cystic Fibrosis Foundation; DOI: 10.13039/100000897, name: Cystic Fibrosis Foundation; name: EnVision Program
Language: English
Date published: 10/2019
Academic Unit: Endocrinology and Diabetes; Stead Family Department of Pediatrics
Record Identifier: 9984354507202771

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