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Hypopituitarism After Mild Traumatic Brain Injury: A Case Report
Journal article   Open access   Peer reviewed

Hypopituitarism After Mild Traumatic Brain Injury: A Case Report

Ryan J. McLoughlin and Randel L Swanson II
Curēus (Palo Alto, CA), Vol.15(7), e41282
07/02/2023
DOI: 10.7759/cureus.41282
PMCID: PMC10317077
PMID: 37405126
url
https://doi.org/10.7759/cureus.41282View
Published (Version of record) Open Access

Abstract

Hypopituitarism is characterized by an underactive pituitary gland and may result in growth hormone deficiency, hypothyroidism, testosterone deficiency, and/or adrenal insufficiency. Traumatic brain injury (TBI) exposure is a known risk factor for hypopituitarism. However, patients with hypopituitarism secondary to TBI exposure may go undiagnosed because the signs and symptoms of hypopituitarism can be subtle. This case report describes a 40-year-old male US military veteran who endorsed fatigue, sexual dysfunction, and weight gain several years after experiencing multiple mild TBIs during his military service. He ultimately underwent a full neuroendocrine workup that revealed low testosterone in addition to previously diagnosed hypothyroidism with a resolution of symptoms after starting testosterone therapy.
General & Internal Medicine Life Sciences & Biomedicine Medicine, General & Internal Science & Technology

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