Hypospadias and intake of nutrients related to one-carbon metabolism

Suzan L Carmichael; Wei Yang; Adolfo Correa; Richard S Olney; Gary M Shaw; National Birth Defects Prevention Study

doi:10.1016/j.juro.2008.09.041

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Hypospadias and intake of nutrients related to one-carbon metabolism

Journal article

Peer reviewed

Hypospadias and intake of nutrients related to one-carbon metabolism

Suzan L Carmichael, Wei Yang, Adolfo Correa, Richard S Olney, Gary M Shaw and National Birth Defects Prevention Study

The Journal of urology, Vol.181(1), pp.315-321

01/2009

DOI: 10.1016/j.juro.2008.09.041

PMID: 19013591

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Abstract

We examined whether hypospadias is associated with maternal intake of folic acid containing vitamin/mineral supplements or dietary intake of nutrients related to one-carbon metabolism (folate, choline, vitamins B12 and B6, thiamine, riboflavin, methionine and zinc). The study included births from October 1997 to December 2003 that were part of the National Birth Defects Prevention Study. Diet was assessed by food frequency questionnaire during maternal telephone interviews. Analyses included 915 cases with second or third degree hypospadias (urethra opened at the penile shaft, scrotum or perineum) and 2,266 male, liveborn, nonmalformed controls. All ORs and 95% CIs were estimated from logistic regression models that included several potential confounders. Nutrient based analyses also included energy intake. Hypospadias risk was not associated with supplement use (adjusted ORs were 1.2, 95% CI 0.9-1.6 for intake beginning in the month before or the first month of pregnancy and 1.1, 95% CI 0.8-1.4 for intake beginning in the second or third month, relative to no intake). Among women who took supplements reduced hypospadias risk was associated with higher dietary intakes of choline, methionine and vitamin B12. The respective ORs (CIs) for the highest vs lowest quartiles were 0.7 (0.5-1.1), 0.6 (0.4-0.9) and 0.7 (0.5-1.0). Among women who did not take supplements increased risk of hypospadias was associated with higher vitamin B12 intake. The OR (CI) for the highest vs lowest quartile was 3.1 (1.1-9.0). This study suggests an association of hypospadias with intake of certain nutrients related to one-carbon metabolism.

Carbon - metabolism

Choline - administration & dosage

Diet

Dietary Supplements

Female

Folic Acid - administration & dosage

Humans

Hypospadias - epidemiology

Infant, Newborn

Male

Methionine - administration & dosage

Pregnancy - metabolism

Prenatal Nutritional Physiological Phenomena

Riboflavin - administration & dosage

Thiamine - administration & dosage

Vitamin B 12 - administration & dosage

Vitamin B 6 - administration & dosage

Zinc - administration & dosage

Details

Title: Subtitle: Hypospadias and intake of nutrients related to one-carbon metabolism
Creators: Suzan L Carmichael - California Research Division, March of Dimes Foundation, Oakland, California, USA. scarmichael@marchofdimes.com
Wei Yang
Adolfo Correa
Richard S Olney
Gary M Shaw
National Birth Defects Prevention Study
Contributors: Paul A Romitti (Contributor) - University of Iowa, Epidemiology
Resource Type: Journal article
Publication Details: The Journal of urology, Vol.181(1), pp.315-321
DOI: 10.1016/j.juro.2008.09.041
PMID: 19013591
ISSN: 0022-5347
eISSN: 1527-3792
Grant note: U50/CCU925286 / PHS HHS DK56350 / NIDDK NIH HHS
Language: English
Date published: 01/2009
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9984214788002771

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