Hypothalamic Corticotrophin-Releasing Factor and Norepinephrine Mediate Sympathetic and Cardiovascular Responses to Acute Intracarotid Injection of Tumour Necrosis Factor-α in the Rat

Z.-H ZHANG; R. B FELDER

doi:10.1111/j.1365-2826.2008.01750.x

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Hypothalamic Corticotrophin-Releasing Factor and Norepinephrine Mediate Sympathetic and Cardiovascular Responses to Acute Intracarotid Injection of Tumour Necrosis Factor-α in the Rat

Journal article

Peer reviewed

Hypothalamic Corticotrophin-Releasing Factor and Norepinephrine Mediate Sympathetic and Cardiovascular Responses to Acute Intracarotid Injection of Tumour Necrosis Factor-α in the Rat

Z.-H ZHANG and R. B FELDER

Journal of neuroendocrinology, Vol.20(8), pp.978-987

2008

DOI: 10.1111/j.1365-2826.2008.01750.x

PMCID: PMC2782651

PMID: 18777604

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Abstract

Systemic administration of tumour necrosis factor (TNF)‐α induces the release of norepinephrine in the paraventricular nucleus (PVN) of hypothalamus and an increase in expression of corticotrophin‐releasing factor (CRF) and CRF type 1 receptors. We explored the hypothesis that CRF and norepinephrine in PVN mediate the cardiovascular and sympathetic responses to acute systemic administration of TNF‐α. In anaesthetised rats, the increases in arterial pressure and heart rate induced by intracarotid artery injection of TNF‐α were attenuated by intracerebroventricular (ICV) injection of either the α1‐adrenergic antagonist prazosin or the CRF antagonist α‐helical CRF. Prazosin blocked the TNF‐α‐induced increase in renal sympathetic nerve activity (RSNA), whereas α‐helical CRF substantially reduced the RSNA response. Conversely, CRF and the α1‐adrenergic agonist phenylephrine, administered ICV, both elicited increases in PVN neuronal activity, RSNA, arterial pressure and heart rate. Microinjection of CRF and phenylephrine directly into PVN evoked smaller responses. These results are consistent with the hypothesis that norepinephrine and CRF in the PVN mediate the cardiovascular and sympathetic responses to acute systemic administration of TNF‐α.

Fundamental and applied biological sciences. Psychology

Vertebrates: nervous system and sense organs

Biological and medical sciences

Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ

Vertebrates: endocrinology

Details

Title: Subtitle: Hypothalamic Corticotrophin-Releasing Factor and Norepinephrine Mediate Sympathetic and Cardiovascular Responses to Acute Intracarotid Injection of Tumour Necrosis Factor-α in the Rat
Creators: Z.-H ZHANG - Department of Internal Medicine, University of Iowa, Iowa, IA, United States
R. B FELDER - Department of Internal Medicine, University of Iowa, Iowa, IA, United States
Resource Type: Journal article
Publication Details: Journal of neuroendocrinology, Vol.20(8), pp.978-987
DOI: 10.1111/j.1365-2826.2008.01750.x
PMID: 18777604
PMCID: PMC2782651
NLM abbreviation: J Neuroendocrinol
ISSN: 0953-8194
eISSN: 1365-2826
Publisher: Blackwell Science; Oxford
Language: English
Date published: 2008
Academic Unit: Iowa Neuroscience Institute; Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984065376802771

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