Hypothyroidism and related comorbidities on the risks of developing tinnitus

Alan Hsu; Yung-An Tsou; Tang-Chuan Wang; Wen-Dien Chang; Cheng-Li Lin; Richard S Tyler

doi:10.1038/s41598-022-07457-0

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Hypothyroidism and related comorbidities on the risks of developing tinnitus

Journal article

Open access

Peer reviewed

Hypothyroidism and related comorbidities on the risks of developing tinnitus

Alan Hsu, Yung-An Tsou, Tang-Chuan Wang, Wen-Dien Chang, Cheng-Li Lin and Richard S Tyler

Scientific reports, Vol.12(1), pp.3401-3401

03/01/2022

DOI: 10.1038/s41598-022-07457-0

PMCID: PMC8888629

PMID: 35233053

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Abstract

This is a retrospective longitudinal study that uses data from the National Health Insurance Research Database (NHIRD) of Taiwan of which hypothyroid patients who received a diagnosis between 2000 and 2010 were selected and followed up until 2011. The primary outcome of this study was the occurrence of tinnitus (ICD-9-CM code 388.3). The relevant comorbidities were selected as potential confounders according to the literature, which included vertigo (ICD-9-CM code 386), insomnia (ICD-9-CM code 780), anxiety (ICD-9-CM code 300.00), and hearing loss (ICD-9-CM code 388-389). The overall incidence of tinnitus was significantly higher in the hypothyroidism cohort than in the non-hypothyroidism cohort (9.49 vs. 6.03 per 1000 person-years), with an adjusted HR of 1.35 (95% CI 1.18-1.54) after adjusting potential confounders. The incidences of tinnitus, as stratified by gender, age, comorbidity, and follow-up time, were all significantly higher in the hypothyroidism cohort than those in the non-hypothyroidism cohort. The incidence of tinnitus significantly increased with age (aHR = 1.01, 95% CI 1.01-1.02). In conclusion, we report the relationship between hypothyroidism and the increased risk for tinnitus. We also found that hypothyroidism patients are at increased risk of developing tinnitus when associated with comorbidities including vertigo, hearing loss, and insomnia.

Comorbidity

Hearing Loss - complications

Hearing Loss - epidemiology

Humans

Hypothyroidism - complications

Hypothyroidism - epidemiology

Incidence

Longitudinal Studies

Retrospective Studies

Risk Factors

Sleep Initiation and Maintenance Disorders - complications

Sleep Initiation and Maintenance Disorders - epidemiology

Taiwan - epidemiology

Tinnitus - epidemiology

Tinnitus - etiology

Vertigo - complications

Details

Title: Subtitle: Hypothyroidism and related comorbidities on the risks of developing tinnitus
Creators: Alan Hsu - Department of Otolaryngology-Head and Neck Surgery, China Medical University Hsinchu Hospital, Zhubei City, Hsinchu County, Taiwan.
Yung-An Tsou - China Medical University
Tang-Chuan Wang - Department of Otolaryngology-Head and Neck Surgery, China Medical University Hsinchu Hospital, Zhubei City, Hsinchu County, Taiwan. tangchuan1020@gmail.com.
Wen-Dien Chang - National Taiwan University
Cheng-Li Lin - China Medical University
Richard S Tyler - University of Iowa
Resource Type: Journal article
Publication Details: Scientific reports, Vol.12(1), pp.3401-3401
DOI: 10.1038/s41598-022-07457-0
PMID: 35233053
PMCID: PMC8888629
NLM abbreviation: Sci Rep
ISSN: 2045-2322
eISSN: 2045-2322
Grant note: DOI: 10.13039/501100004391, name: China Medical University Hospital, award: CMU107-N-30; name: Taiwan Ministry of Health and Welfare Clinical Trial Center, award: MOHW109-TDU-B-212-114004; name: Tseng-Lien Lin Foundation
Language: English
Date published: 03/01/2022
Academic Unit: Communication Sciences and Disorders; Otolaryngology
Record Identifier: 9984258745202771

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