Journal article
Hypoxia recruits intrapulmonary arteriovenous pathways in intact rats but not isolated rat lungs
Journal of applied physiology (1985), Vol.112(11), pp.1915-1920
06/01/2012
DOI: 10.1152/japplphysiol.00985.2011
PMCID: PMC3379154
PMID: 22422800
Abstract
Intrapulmonary arteriovenous anastomoses (IPAVS) directly connect the arterial and venous circulations in the lung, bypassing the capillary network. Here, we used solid, latex microspheres and isolated rat lung and intact, spontaneously breathing rat models to test the hypothesis that IPAVS are recruited by alveolar hypoxia. We found that hypoxia recruits IPAVS in the intact rat, but not the isolated lung. IPAVS are at least 70 μm in the rat and, interestingly, appear to be recruited when the mixed venous P
o
2
falls below 22 mmHg. These data provide evidence that large-diameter, direct arteriovenous connections exist in the lung and are recruitable by hypoxia in the intact animal.
Details
- Title: Subtitle
- Hypoxia recruits intrapulmonary arteriovenous pathways in intact rats but not isolated rat lungs
- Creators
- Melissa L Bates - Department of Pediatrics and the John Rankin Laboratory of Pulmonary MedicineBrendan R Fulmer - Department of Pediatrics and the John Rankin Laboratory of Pulmonary MedicineEmily T Farrell - Department of Pediatrics and the John Rankin Laboratory of Pulmonary MedicineAlyssa Drezdon - Department of Pediatrics and the John Rankin Laboratory of Pulmonary MedicineDavid F Pegelow - Department of Pediatrics and the John Rankin Laboratory of Pulmonary MedicineRobert L Conhaim - Department of Surgery, University of Wisconsin School of Medicine and Public Health, and William S. Middleton Memorial Veterans Hospital, Madison, WisconsinMarlowe W Eldridge - Departments of Biomedical Engineering and Kinesiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; and
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.112(11), pp.1915-1920
- DOI
- 10.1152/japplphysiol.00985.2011
- PMID
- 22422800
- PMCID
- PMC3379154
- NLM abbreviation
- J Appl Physiol (1985)
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Publisher
- American Physiological Society; Bethesda, MD
- Grant note
- 5R01-HL-086897; 5T32-HL-007654 / National Institutes of Health
- Language
- English
- Date published
- 06/01/2012
- Academic Unit
- Stead Family Department of Pediatrics; Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984002343102771
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