Hysterectomy, Oophorectomy, and Risk of Renal Cell Carcinoma

Juhua Luo; Thomas E Rohan; Marian L Neuhouser; Nianjun Liu; Nazmus Saquib; Yueyao Li; Aladdin H Shadyab; Lihong Qi; Robert B Wallace; Michael Hendryx

doi:10.1158/1055-9965.EPI-20-1373

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Hysterectomy, Oophorectomy, and Risk of Renal Cell Carcinoma

Journal article

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Peer reviewed

Hysterectomy, Oophorectomy, and Risk of Renal Cell Carcinoma

Juhua Luo, Thomas E Rohan, Marian L Neuhouser, Nianjun Liu, Nazmus Saquib, Yueyao Li, Aladdin H Shadyab, Lihong Qi, Robert B Wallace and Michael Hendryx

Cancer epidemiology, biomarkers & prevention, Vol.30(3), pp.499-506

03/2021

DOI: 10.1158/1055-9965.EPI-20-1373

PMID: 33335021

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Abstract

Female hormones may play roles during renal cell carcinoma (RCC) carcinogenesis. The aims of this study were to investigate associations between hysterectomy, oophorectomy, and risk of RCC and to assess whether the associations were modified by exogenous estrogen, commonly used among women who have undergone hysterectomy. Postmenopausal women ( = 144,599) ages 50-79 years at enrollment (1993-1998) in the Women's Health Initiative were followed for a mean of 15.9 years. Hysterectomy and oophorectomy were self-reported. Incident RCC cases were confirmed by physician review of medical records and pathology reports. Multivariable Cox proportional hazards modeling was used to estimate hazard ratios (HR) and 95% confidence intervals (CI), adjusting for potential confounders. A total of 583 women developed RCC during follow-up. We observed that hysterectomy, regardless of oophorectomy status, was significantly associated with an increased risk of RCC (HR, 1.28; 95% CI, 1.03-1.60). The association appeared to be more pronounced in women with age at hysterectomy younger than 40 years (HR, 1.34; 95% CI, 1.01-1.80) or older than 55 years (HR, 1.52; 95% CI, 1.01-2.29). Oophorectomy was not significantly associated with risk of RCC. There was no evidence that exogenous estrogen use modified the association between hysterectomy and risk of RCC. In this large prospective study, we showed that women with a history of hysterectomy had 28% increased risk of RCC, and this finding was not modified by exogenous hormone use. If our findings are confirmed, women should be made aware of increased risk of RCC when considering hysterectomy.

Aged

Carcinoma, Renal Cell - etiology

Carcinoma, Renal Cell - pathology

Female

Humans

Hysterectomy - adverse effects

Kidney Neoplasms - etiology

Kidney Neoplasms - pathology

Middle Aged

Ovariectomy - adverse effects

Risk Factors

Women's Health

Details

Title: Subtitle: Hysterectomy, Oophorectomy, and Risk of Renal Cell Carcinoma
Creators: Juhua Luo - Indiana University
Thomas E Rohan - Albert Einstein College of Medicine
Marian L Neuhouser - Fred Hutch Cancer Center
Nianjun Liu - Indiana University
Nazmus Saquib - Sulaiman Al Rajhi Colleges
Yueyao Li - Brown University
Aladdin H Shadyab - University of California - San Diego School of Medicine
Lihong Qi - University of California, Davis
Robert B Wallace - University of Iowa
Michael Hendryx - Indiana University
Resource Type: Journal article
Publication Details: Cancer epidemiology, biomarkers & prevention, Vol.30(3), pp.499-506
DOI: 10.1158/1055-9965.EPI-20-1373
PMID: 33335021
NLM abbreviation: Cancer Epidemiol Biomarkers Prev
ISSN: 1055-9965
eISSN: 1538-7755
Grant note: HHSN268201600018C / NHLBI NIH HHS HHSN268201600003C / NHLBI NIH HHS HHSN268201600004C / NHLBI NIH HHS HHSN268201600002C / NHLBI NIH HHS HHSN268201600001C / NHLBI NIH HHS
Language: English
Date published: 03/2021
Academic Unit: Epidemiology; Injury Prevention Research Center; Internal Medicine
Record Identifier: 9984363575802771

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