Journal article
ICU and Ventilator Mortality Among Critically Ill Adults With Coronavirus Disease 2019
Critical care medicine, Vol.48(9), pp.e799-e804
09/2020
DOI: 10.1097/CCM.0000000000004457
PMCID: PMC7255393
PMID: 32452888
Abstract
To determine mortality rates among adults with critical illness from coronavirus disease 2019.
Observational cohort study of patients admitted from March 6, 2020, to April 17, 2020.
Six coronavirus disease 2019 designated ICUs at three hospitals within an academic health center network in Atlanta, Georgia, United States.
Adults greater than or equal to 18 years old with confirmed severe acute respiratory syndrome-CoV-2 disease who were admitted to an ICU during the study period.
None.
Among 217 critically ill patients, mortality for those who required mechanical ventilation was 35.7% (59/165), with 4.8% of patients (8/165) still on the ventilator at the time of this report. Overall mortality to date in this critically ill cohort is 30.9% (67/217) and 60.4% (131/217) patients have survived to hospital discharge. Mortality was significantly associated with older age, lower body mass index, chronic renal disease, higher Sequential Organ Failure Assessment score, lower PaO2/FIO2 ratio, higher D-dimer, higher C-reactive protein, and receipt of mechanical ventilation, vasopressors, renal replacement therapy, or vasodilator therapy.
Despite multiple reports of mortality rates exceeding 50% among critically ill adults with coronavirus disease 2019, particularly among those requiring mechanical ventilation, our early experience indicates that many patients survive their critical illness.
Details
- Title: Subtitle
- ICU and Ventilator Mortality Among Critically Ill Adults With Coronavirus Disease 2019
- Creators
- Sara C AuldMark Caridi-Scheible - Department of Anesthesiology, Emory University School of Medicine, Atlanta, GAJames M Blum - Georgia Clinical and Translational Science Alliance (CTSA), Atlanta, GAChad Robichaux - Georgia Clinical and Translational Science Alliance (CTSA), Atlanta, GAColleen Kraft - Department of Pathology, Emory University School of Medicine, Atlanta, GAJesse T Jacob - Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GACraig S Jabaley - Department of Anesthesiology, Emory University School of Medicine, Atlanta, GADavid Carpenter - Emory UniversityRoberta Kaplow - Emory University Hospital, Emory Healthcare, Atlanta, GAAlfonso C Hernandez-Romieu - Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GAMax W Adelman - Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GAGreg S Martin - Georgia Clinical and Translational Science Alliance (CTSA), Atlanta, GACraig M Coopersmith - Department of Surgery, Emory University School of Medicine, Atlanta, GADavid J Murphy - Office of Quality and Risk, Emory Healthcare, Atlanta, GA
- Resource Type
- Journal article
- Publication Details
- Critical care medicine, Vol.48(9), pp.e799-e804
- DOI
- 10.1097/CCM.0000000000004457
- PMID
- 32452888
- PMCID
- PMC7255393
- NLM abbreviation
- Crit Care Med
- ISSN
- 0090-3493
- eISSN
- 1530-0293
- Publisher
- United States
- Grant note
- K23 AI134182 / NIAID NIH HHS UL1 TR002378 / NCATS NIH HHS
- Language
- English
- Date published
- 09/2020
- Academic Unit
- Anesthesia
- Record Identifier
- 9984013164002771
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