Journal article
IDENTIFYING NEW SUDDEN DEATH GENES
Transactions of the American Clinical and Climatological Association, Vol.129, pp.183-184
01/01/2018
PMCID: PMC6116611
PMID: 30166713
Abstract
Inherited conditions that lead to cardiac arrhythmias and sudden cardiac death remain an important cause of morbidity and mortality. Identifying the genes responsible for these rare conditions can provide insights into the more common and heritable forms of sudden cardiac death seen in patients with structural heart disease. We and others have used candidate gene approaches and positional cloning in large families to show that mutations in ion channels and ion channel related proteins cause familial arrhythmia syndromes including long QT and Brugada syndromes. The genes responsible for many familial arrhythmia syndromes and the vast majority of the predisposition to common arrhythmias remain unknown. Using whole exome sequencing in families with Brugada syndrome and idiopathic ventricular fibrillation, we now seek to identify mutations in genes previously not thought to play a significant role in the heart.
Details
- Title: Subtitle
- IDENTIFYING NEW SUDDEN DEATH GENES
- Creators
- BARRY London - IOWA CITY, IOWAALEXANDER M. Greiner - IOWA CITY, IOWAHAIDER Mehdi - IOWA CITY, IOWAREBECCA Gutmann - IOWA CITY, IOWA
- Resource Type
- Journal article
- Publication Details
- Transactions of the American Clinical and Climatological Association, Vol.129, pp.183-184
- Publisher
- American Clinical and Climatological Association
- PMID
- 30166713
- PMCID
- PMC6116611
- ISSN
- 0065-7778
- Language
- English
- Date published
- 01/01/2018
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984297499602771
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