Journal article
IGF-I and IGFBP-3 transport in the rat heart
American journal of physiology: endocrinology and metabolism, Vol.284(1), pp.E237-E239
01/01/2003
DOI: 10.1152/ajpendo.00336.2002
PMID: 12485812
Abstract
Specific binding of IGF-binding protein (IGFBP)-3 was shown to be present in the isolated, beating rat heart. The uptake of perfused 125I-labeled IGF-I in the beating heart was decreased to 9% by blocking IGF-I binding sites with the IGF-I analog Long R3 (LR3) IGF-I. When LR3 was perfused with complexes of125I-IGF-I · IGFBP-3, uptake of125I-IGF-I was decreased to 41%, which was significantly greater than LR3 and 125I-IGF-I (41 vs. 9%). These data suggest that both microvessel IGF-I and IGFBP-3 binding sites contribute to the transport of IGF-I in the perfused rat heart. This also suggests a novel and plausible mechanism whereby circulating IGFs reach sites of IGF bioactivity.
Details
- Title: Subtitle
- IGF-I and IGFBP-3 transport in the rat heart
- Creators
- Mary Boes - United States Department of Veterans AffairsBrian L. Dake - Internal Medicine andBarbara A. Booth - University of IowaAlexander Sandra - University of IowaMathew Bateman - Institute of Cell Biology and NeurobiologyKevin L. Knudtson - University of IowaRobert S. Bar - University of Iowa
- Resource Type
- Journal article
- Publication Details
- American journal of physiology: endocrinology and metabolism, Vol.284(1), pp.E237-E239
- DOI
- 10.1152/ajpendo.00336.2002
- PMID
- 12485812
- NLM abbreviation
- Am J Physiol Endocrinol Metab
- ISSN
- 0193-1849
- eISSN
- 1522-1555
- Language
- English
- Date published
- 01/01/2003
- Academic Unit
- Anatomy and Cell Biology; Endocrinology and Metabolism; Internal Medicine; Iowa Institute of Human Genetics
- Record Identifier
- 9984627211502771
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