Journal article
IGF‐1 receptor deficiency in thyrocytes impairs thyroid hormone secretion and completely inhibits TSH‐stimulated goiter
The FASEB journal, Vol.27(12), pp.4899-4908
11/2013
DOI: 10.1096/fj.13-231381
PMID: 23982142
Abstract
Although thyroid‐stimulating hormone (TSH) is known to be a major regulator of thyroid hormone biosynthesis and thyroid growth, insulin‐like growth factor 1 (IGF‐1) is required for mediating thyrocyte growth in concert with TSH in vitro. We generated mice with thyrocyte‐selective ablation of IGF‐1 receptor (TIGF1RKO) to explore the role of IGF‐1 receptor signaling on thyroid function and growth. In 5‐wk‐old TIGF1RKO mice, serum thyroxine (T4) concentrations were decreased by 30% in concert with a 43% down‐regulation of the monocarboxylate transporter 8 (MCT8), which is involved in T4 secretion. Despite a 3.5‐fold increase in circulating concentrations of TSH, thyroid architecture and size were normal. Furthermore, thyrocyte area was increased by 40% in WT thyroids after 10 d TSH injection, but this effect was absent in TSH‐injected TIGF1RKO mice. WT mice treated with methimazole and sodium perchlorate for 2 or 6 wk exhibited pronounced goiter development (2.0 and 5.4‐fold, respectively), but in TIGF1RKO mice, goiter development was completely abrogated. These data reveal an essential role for IGF‐1 receptor signaling in the regulation of thyroid function and TSH‐stimulated goitrogenesis.—Ock, S., Ahn, J., Lee, S. H., Kang, H., Offermanns, S., Ahn, H. Y., Jo, Y.S., Shong, M., Cho, B. Y., Jo, D., Abel, E. D., Lee, T. J., Park, W. J., Lee, I.‐K., Kim, J. IGF‐1 receptor deficiency in thyrocytes impairs thyroid hormone secretion and completely inhibits TSH‐stimulated goiter. FASEB J. 27, 4899–4908 (2013). www.fasebj.org
Details
- Title: Subtitle
- IGF‐1 receptor deficiency in thyrocytes impairs thyroid hormone secretion and completely inhibits TSH‐stimulated goiter
- Creators
- Sangmi Ock - Chung‐Ang UniversityJihyun Ahn - Chung‐Ang UniversitySeok Hong Lee - Chung‐Ang UniversityHyun Kang - Chung‐Ang UniversityStefan Offermanns - Max Planck Institute for Heart and Lung ResearchHwa Young Ahn - Chung‐Ang UniversityYoung Suk Jo - Chungnam National University HospitalMinho Shong - Chungnam National University HospitalBo Youn Cho - Chung‐Ang UniversityDaewoong Jo - Vanderbilt University School of MedicineE. Dale Abel - University of Utah School of MedicineTae Jin Lee - Chung‐Ang UniversityWoo Jin Park - Gwangju Institute of Science and TechnologyIn‐Kyu Lee - Kyungpook National University School of MedicineJaetaek Kim - Chung‐Ang University
- Resource Type
- Journal article
- Publication Details
- The FASEB journal, Vol.27(12), pp.4899-4908
- DOI
- 10.1096/fj.13-231381
- PMID
- 23982142
- NLM abbreviation
- FASEB J
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Publisher
- Federation of American Societies for Experimental Biology; Bethesda, MD, USA
- Number of pages
- 10
- Grant note
- Korea Ministry of Health and Welfare Korea Healthcare Technology R&D Project (A084811) National Research Foundation (2012R1A1A2043642) Ministry of Education, Republic of Korea
- Language
- English
- Date published
- 11/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984025269402771
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