IL-1 receptor antagonist release is regulated differently in human alveolar macrophages than in monocytes

Joel N Kline; Martha M Monick; Gary W Hunninghake

doi:10.1152/jappl.1992.73.4.1686

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IL-1 receptor antagonist release is regulated differently in human alveolar macrophages than in monocytes

Journal article

Peer reviewed

IL-1 receptor antagonist release is regulated differently in human alveolar macrophages than in monocytes

Joel N Kline, Martha M Monick and Gary W Hunninghake

Journal of applied physiology (1985), Vol.73(4), pp.1686-1692

10/01/1992

DOI: 10.1152/jappl.1992.73.4.1686

PMID: 1447122

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Abstract

These studies compared the release of interleukin-1 receptor antagonist (IL-1 RA) from alveolar macrophages and peripheral blood monocytes. The cells were cultured in medium containing various amounts of heat-inactivated fetal calf serum (FCS), granulocyte-macrophage colony-stimulating factor (GM-CSF), lipopolysaccharide (LPS), and immunoglobulin G (IgG). In serum-free medium alone, IL-1 RA release was similar from macrophages and monocytes. Increasing FCS concentration caused a significant upregulation of IL-1 RA release in macrophages but not in monocytes. GM-CSF caused a small increase in both cell types. LPS caused downregulation of IL-1 RA release from monocytes but not from macrophages. IgG did not affect IL-1 RA release in either cell group. These studies demonstrate that regulation of IL-1 RA release is different in monocytes and macrophages.

Details

Title: Subtitle: IL-1 receptor antagonist release is regulated differently in human alveolar macrophages than in monocytes
Creators: Joel N Kline - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242
Martha M Monick - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242
Gary W Hunninghake - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242
Resource Type: Journal article
Publication Details: Journal of applied physiology (1985), Vol.73(4), pp.1686-1692
DOI: 10.1152/jappl.1992.73.4.1686
PMID: 1447122
NLM abbreviation: J Appl Physiol (1985)
ISSN: 8750-7587
eISSN: 1522-1601
Language: English
Date published: 10/01/1992
Academic Unit: Pulmonary, Critical Care, and Occupational Medicine; Occupational and Environmental Health; Internal Medicine
Record Identifier: 9984094654602771

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