Journal article
IL-10 Dampens an IL-17-Mediated Periodontitis-Associated Inflammatory Network
The Journal of immunology (1950), Vol.204(8), pp.2177-2191
04/15/2020
DOI: 10.4049/jimmunol.1900532
PMCID: PMC7840149
PMID: 32169848
Abstract
Emerging evidence suggests comprehensive immune profiling represents a highly promising, yet insufficiently tapped approach to identify potentially prognostic signatures for periodontitis. In this report, we agnostically identified a periodontitis-associated inflammatory expression network with multiple biomarkers identified within gingival crevicular fluid samples from study participants by applying principal component analysis. We identified an IL-17-dominated trait that is associated with periodontal disease and is inversely modified by the level of IL-10. IL-10 mitigated chemokine CXCL5 and CXCL1 expressions in IL-17-stimulated peripheral blood monocytic cells and peripheral blood monocytic cell-derived macrophages.
-deficient mice presented more bone loss, which was associated with more
and IL-17-mediated chemokine and cytokine expression at the transcriptional levels in comparison with control wild-type mice in both the
-induced experimental murine periodontitis and ligature-induced alveolar bone-loss models. The dampening effect of IL-10 on the excessive signaling of IL-17 appeared to be mediated by innate immune cells populations rather than by gingival epithelial cells, which are the major cell target for IL-17 signaling. Additionally, elevated IL-17 response in
-deficient mice specifically elicited an M1-skewing macrophage phenotype in the gingiva that was associated with the advanced bone loss in the ligature model. In summary, IL-17 dominated an inflammatory network characteristic of periodontitis, and IL-10 dampens this excessive IL-17-mediated periodontitis trait.
Details
- Title: Subtitle
- IL-10 Dampens an IL-17-Mediated Periodontitis-Associated Inflammatory Network
- Creators
- Lu Sun - Oral and Craniofacial Biomedicine Program, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599Mustafa Girnary - Department of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599Lufei Wang - Oral and Craniofacial Biomedicine Program, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599Yizu Jiao - Doctor of Dental Surgery Program, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599Erliang Zeng - Division of Biostatistics and Computational Biology, University of Iowa College of Dentistry, Iowa City, IA 52242Jinmei Zhang - State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, ChinaJulie T Marchesan - Department of Oral and Craniofacial Health Sciences, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599Ning Yu - Center for Clinical and Translational Research, The Forsyth Institute, Cambridge, MA 02142Kevin Moss - Department of Dental Ecology, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; andYu L Lei - Department of Periodontics and Oral Medicine, Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109Steven Offenbacher - Center for Oral and Systemic Diseases, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599Shaoping Zhang - Iowa Institute for Oral Health Research, University of Iowa College of Dentistry, Iowa City, IA 52242
- Resource Type
- Journal article
- Publication Details
- The Journal of immunology (1950), Vol.204(8), pp.2177-2191
- DOI
- 10.4049/jimmunol.1900532
- PMID
- 32169848
- PMCID
- PMC7840149
- NLM abbreviation
- J Immunol
- ISSN
- 0022-1767
- eISSN
- 1550-6606
- Publisher
- United States
- Grant note
- K99 DE027086 / NIDCR NIH HHS R00 DE024173 / NIDCR NIH HHS R01 DE021418 / NIDCR NIH HHS R01 DE026728 / NIDCR NIH HHS R01 DE023836 / NIDCR NIH HHS
- Language
- English
- Date published
- 04/15/2020
- Academic Unit
- Preventive and Community Dentistry; Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute; Biostatistics; Dental Research; Periodontics
- Record Identifier
- 9984070406302771
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