Journal article
IL-17: Balancing Protective Immunity and Pathogenesis
Journal of immunology research, Vol.2023, pp.1-9
08/12/2023
DOI: 10.1155/2023/3360310
PMCID: PMC10439834
PMID: 37600066
Abstract
The biological role of interleukin 17 (IL-17) has been explored during recent decades and identified as a pivotal player in coordinating innate and adaptive immune responses. Notably, IL-17 functions as a double-edged sword with both destructive and protective immunological roles. While substantial progress has implicated unrestrained IL-17 in a variety of infectious diseases or autoimmune conditions, IL-17 plays an important role in protecting the host against pathogens and maintaining physiological homeostasis. In this review, we describe canonical IL-17 signaling mechanisms promoting neutrophils recruitment, antimicrobial peptide production, and maintaining the epithelium barrier integrity, as well as some noncanonical mechanisms involving IL-17 that elicit protective immunity.
Details
- Title: Subtitle
- IL-17: Balancing Protective Immunity and Pathogenesis
- Creators
- Lu Sun - Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USALufei Wang - University of North Carolina at Chapel HillBethany B. Moore - University of MichiganShaoping Zhang - University of IowaPeng Xiao - Sir Run Run Shaw HospitalAnn M. Decker - University of MichiganHom-Lay Wang - University of Michigan
- Contributors
- Baohui Xu (Editor)
- Resource Type
- Journal article
- Publication Details
- Journal of immunology research, Vol.2023, pp.1-9
- DOI
- 10.1155/2023/3360310
- PMID
- 37600066
- PMCID
- PMC10439834
- NLM abbreviation
- J Immunol Res
- ISSN
- 2314-8861
- eISSN
- 2314-7156
- Grant note
- DOI: 10.13039/100008115, name: School of Dentistry, University of Michigan
- Language
- English
- Date published
- 08/12/2023
- Academic Unit
- Periodontics
- Record Identifier
- 9984455490402771
Metrics
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