IL-17 signaling in host defense and inflammatory diseases

Youcun Qian; Zizhen Kang; Caini Liu; Xiaoxia Li

doi:10.1038/cmi.2010.27

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IL-17 signaling in host defense and inflammatory diseases

Journal article

Open access

Peer reviewed

IL-17 signaling in host defense and inflammatory diseases

Youcun Qian, Zizhen Kang, Caini Liu and Xiaoxia Li

Cellular & molecular immunology, Vol.7(5), pp.328-333

09/2010

DOI: 10.1038/cmi.2010.27

PMCID: PMC4002676

PMID: 20514051

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Abstract

Interleukin (IL)-17, the signature cytokine secreted by T helper (Th) 17 cells, plays important roles in host defense against extracellular bacterial infection and fungal infection and contributes to the pathogenesis of various autoimmune inflammatory diseases. Here we review the recent advances in IL-17-mediated functions with emphasis on the studies of IL-17-mediated signal transduction, providing perspective on potential drug targets for the treatment of autoimmune inflammatory diseases.

inflammation

interleukin-17

Review

signaling

Details

Title: Subtitle: IL-17 signaling in host defense and inflammatory diseases
Creators: Youcun Qian - Shanghai Jiao Tong University
Zizhen Kang - Cleveland Clinic
Caini Liu - Cleveland Clinic
Xiaoxia Li - Cleveland Clinic
Resource Type: Journal article
Publication Details: Cellular & molecular immunology, Vol.7(5), pp.328-333
DOI: 10.1038/cmi.2010.27
PMID: 20514051
PMCID: PMC4002676
NLM abbreviation: Cell Mol Immunol
ISSN: 1672-7681
eISSN: 2042-0226
Publisher: Nature Publishing Group
Language: English
Date published: 09/2010
Academic Unit: Pathology; Iowa Neuroscience Institute
Record Identifier: 9984201117102771

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