Journal article
IL-18 as a biomarker linking systemic juvenile idiopathic arthritis and macrophage activation syndrome
Rheumatology (Oxford, England), Vol.59(2), pp.361-366
02/01/2020
DOI: 10.1093/rheumatology/kez282
PMCID: PMC7571484
PMID: 31326996
Abstract
Systemic juvenile idiopathic arthritis (sJIA) is a childhood arthritis with features of autoinflammation and high risk of macrophage activation syndrome (MAS). IL-18 has been shown to have key roles in sJIA and MAS. We aimed to examine IL-18 levels in sJIA in relation to disease activity and history of MAS and other disease biomarkers namely S100 proteins and CXCL9.
Total IL-18, CXCL9 and S100 proteins levels were determined in 40 sJIA patients, and IL-18 levels were compared between patients with regards to disease activity, history of MAS, and other biomarkers.
Total IL-18 levels were significantly higher in patients with active sJIA (median 16 499 pg/ml; interquartile range (IQR) 4816-61 839), and remained persistently elevated even in the majority of patients with inactive disease (1164 pg/ml; IQR 587-3444). Patients with history of MAS had significantly higher IL-18 levels (13 380 pg/ml; IQR 4212-62 628) as compared with those without MAS history (956.5 pg/ml; IQR 276.3-4262.5). Total IL-18 performed well with area under the curve of 0.8145 and 0.84 in predicting disease activity and history of MAS, respectively. We observed moderate correlation between IL-18 and CXCL9 (R = 0.56), S100A8/A9 (R = 0.47) and S100A12 (R = 0.46). The correlation was stronger for ferritin (R = 0.74) and overall for those with active disease.
Total IL-18 levels were elevated in the majority of sJIA patients regardless of clinical features, but were higher in patients with active disease and history of MAS. Change in IL-18 may reflect increased disease activity or development of MAS.
Details
- Title: Subtitle
- IL-18 as a biomarker linking systemic juvenile idiopathic arthritis and macrophage activation syndrome
- Creators
- Shima Yasin - Cincinnati Children's Hospital Medical CenterNdate Fall - Cincinnati Children's Hospital Medical CenterRachel A Brown - Cincinnati Children's Hospital Medical CenterMaggie Henderlight - Cincinnati Children's Hospital Medical CenterScott W Canna - Children's Hospital of PittsburghCharlotte Girard-Guyonvarc'h - University of GenevaCem Gabay - University of GenevaAlexei A Grom - Cincinnati Children's Hospital Medical CenterGrant S Schulert - University of Cincinnati
- Resource Type
- Journal article
- Publication Details
- Rheumatology (Oxford, England), Vol.59(2), pp.361-366
- DOI
- 10.1093/rheumatology/kez282
- PMID
- 31326996
- PMCID
- PMC7571484
- ISSN
- 1462-0324
- eISSN
- 1462-0332
- Grant note
- K22 AI123366 / NIAID NIH HHS T32 AR069512 / NIAMS NIH HHS K08 AR072075 / NIAMS NIH HHS
- Language
- English
- Date published
- 02/01/2020
- Academic Unit
- Stead Family Department of Pediatrics
- Record Identifier
- 9984354007702771
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