Journal article
IL-1R-IRAKM-Slc25a1 signaling axis reprograms lipogenesis in adipocytes to promote diet-induced obesity in mice
Nature communications, Vol.13(1), pp.1-17
05/01/2022
DOI: 10.1038/s41467-022-30470-w
PMCID: PMC9117277
PMID: 35585086
Abstract
TLRs/IL-1R signaling play a role in high-fat diet induced adipose tissue dysfunction and obesity-associated metabolic syndrome. Here the authors report that adipocyte-specific deficiency of IL-1 Receptor-Associated Kinase M (IRAKM) ameliorates diet induced obesity, potentially via the mitochondrial citrate carrier Slc25a1 and reduced de novo lipogenesis.
Details
- Title: Subtitle
- IL-1R-IRAKM-Slc25a1 signaling axis reprograms lipogenesis in adipocytes to promote diet-induced obesity in mice
- Creators
- Weiwei Liu - Cleveland ClinicHao Zhou - Cleveland ClinicHan Wang - Cleveland ClinicQuanri Zhang - Cleveland ClinicRenliang Zhang - Cleveland ClinicBelinda Willard - Cleveland ClinicCaini Liu - Cleveland ClinicZizhen Kang - University of IowaXiao Li - Case Western Reserve UniversityXiaoxia Li - Cleveland Clinic
- Resource Type
- Journal article
- Publication Details
- Nature communications, Vol.13(1), pp.1-17
- DOI
- 10.1038/s41467-022-30470-w
- PMID
- 35585086
- PMCID
- PMC9117277
- NLM abbreviation
- Nat Commun
- eISSN
- 2041-1723
- Publisher
- Nature Portfolio
- Grant note
- DOI: 10.13039/100008136, name: Case Western Reserve University, award: departmental start-up funding
- Language
- English
- Date published
- 05/01/2022
- Academic Unit
- Pathology; Iowa Neuroscience Institute
- Record Identifier
- 9984259257502771
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