Journal article
IL-5 mediates monocyte phenotype and pain outcomes in fibromyalgia
Pain (Amsterdam), Vol.162(5), pp.1468-1482
05/01/2021
DOI: 10.1097/j.pain.0000000000002089
PMCID: PMC7987864
PMID: 33003107
Abstract
Fibromyalgia (FM) is characterized by widespread chronic pain, fatigue, and somatic symptoms. The influence of phenotypic changes in monocytes on symptoms associated with FM is not fully understood. The primary aim of this study was to take a comprehensive whole-body to molecular approach in characterizing relationships between monocyte phenotype and FM symptoms in relevant clinical populations. Lipopolysaccharide-evoked and spontaneous secretion of IL-5 and other select cytokines from circulating monocytes was higher in women with FM compared to women without pain. In addition, greater secretion of IL-5 was significantly associated with pain and other clinically relevant psychological and somatic symptoms of FM. Furthermore, higher levels of pain and pain-related symptoms were associated with a lower percentage of intermediate monocytes (CD14++/CD16+) and a greater percentage of nonclassical monocytes (CD14+/CD16++) in women with FM. Based on findings from individuals with FM, we examined the role of IL-5, an atypical cytokine secreted from monocytes, in an animal model of widespread muscle pain. Results from the animal model show that IL-5 produces analgesia and polarizes monocytes toward an anti-inflammatory phenotype (CD206+). Taken together, our data suggest that monocyte phenotype and their cytokine profiles are associated with pain-related symptoms in individuals with FM. Furthermore, our data show that IL-5 has a potential role in analgesia in an animal model of FM. Thus, targeting anti-inflammatory cytokines such as IL-5 secreted by circulating leukocytes could serve as a promising intervention to control pain and other somatic symptoms associated with FM.
Details
- Title: Subtitle
- IL-5 mediates monocyte phenotype and pain outcomes in fibromyalgia
- Creators
- Ericka N Merriwether - Neurobiology of Pain Lab, Department of Physical Therapy and Rehabilitation Science, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesNilesh M Agalave - Neuroimmunology and Behavior Lab, School of Brain and Behavioral Science, Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, United StatesDana L Dailey - Department of Physical Therapy, Center for Health Sciences, St. Ambrose University, Davenport, IA, United StatesBarbara A Rakel - College of Nursing, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesSandra J Kolker - Neurobiology of Pain Lab, Department of Physical Therapy and Rehabilitation Science, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesMelissa E Lenert - Neuroimmunology and Behavior Lab, School of Brain and Behavioral Science, Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, United StatesWilliam H Spagnola - Department of Applied Statistics, Social Science, and Humanities, NYU Steinhardt School of Culture, Education, and Human Development, New York University, New York, NY, United StatesYing Lu - Department of Applied Statistics, Social Science, and Humanities, NYU Steinhardt School of Culture, Education, and Human Development, New York University, New York, NY, United StatesKatharine M Geasland - Neurobiology of Pain Lab, Department of Physical Therapy and Rehabilitation Science, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, United StatesLee-Ann H Allen - Departments of Medicine, Microbiology, Immunology, University of Iowa, Iowa City, IA, United StatesMichael D Burton - Neuroimmunology and Behavior Lab, School of Brain and Behavioral Science, Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, United StatesKathleen A Sluka - Neurobiology of Pain Lab, Department of Physical Therapy and Rehabilitation Science, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, United States
- Resource Type
- Journal article
- Publication Details
- Pain (Amsterdam), Vol.162(5), pp.1468-1482
- DOI
- 10.1097/j.pain.0000000000002089
- PMID
- 33003107
- PMCID
- PMC7987864
- NLM abbreviation
- Pain
- ISSN
- 0304-3959
- eISSN
- 1872-6623
- Publisher
- United States
- Grant note
- K22 NS096030 / NINDS NIH HHS UM1 AR063381 / NIAMS NIH HHS U54 TR001356 / NCATS NIH HHS UL1 TR000445 / NCATS NIH HHS L30 AR074203 / NIAMS NIH HHS U54 TR001013 / NCATS NIH HHS
- Language
- English
- Date published
- 05/01/2021
- Academic Unit
- Clinical Research Unit; Microbiology and Immunology; Infectious Diseases; Iowa Neuroscience Institute; Nursing; Anesthesia; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984070443902771
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