Journal article
IM interferon beta-1a delays definite multiple sclerosis 5 years after a first demyelinating event
Neurology, Vol.66(5), pp.678-684
03/14/2006
DOI: 10.1212/01.wnl.0000200778.65597.ae
PMID: 16436649
Abstract
The Controlled High Risk Subjects Avonex Multiple Sclerosis Prevention Study (CHAMPS) showed that IM interferon beta-1a (IFNbeta-1a) significantly slows the rate of development of clinically definite multiple sclerosis (CDMS) over 2 years in high-risk patients who experience a first clinical demyelinating event. This report highlights the primary results of a 5-year, open-label extension of CHAMPS (the Controlled High Risk Avonex Multiple Sclerosis Prevention Study in Ongoing Neurologic Surveillance [CHAMPIONS Study]).
To determine if the benefits of IFNbeta-1a observed in CHAMPS are sustained for up to 5 years.
CHAMPS patients at participating CHAMPIONS sites were enrolled in the study. All patients were offered, but not required to take, IFNbeta-1a 30 microg IM once weekly for up to 5 years (from CHAMPS randomization). Patients who received placebo in CHAMPS were considered the delayed treatment (DT) group, and patients who received IFNbeta-1a in CHAMPS were considered the immediate treatment (IT) group. The primary outcome measure was the rate of development of CDMS. Additional outcomes included disease state classification at 5 years, annualized relapse rates, disability level at 5 years (Expanded Disability Status Scale), and MRI measures at 5 years.
Fifty-three percent (203/383) of patients enrolled in CHAMPIONS (n = 100, IT group; n = 103, DT group) and 64% (32/50) of CHAMPS study sites participated in CHAMPIONS. The median time to initiation of IFNbeta-1a therapy in the DT group was 29 months. The cumulative probability of development of CDMS was significantly lower in the IT group compared with the DT group (5-year incidence 36 +/- 9 vs 49 +/- 10%; p = 0.03). Multivariate analysis suggested that the only factors independently associated with an increased rate of development of CDMS were randomization to the DT group and younger age at onset of neurologic symptoms. Few patients in either group developed major disability within 5 years.
These results support the use of IM interferon beta-1a after a first clinical demyelinating event and indicate that there may be modest beneficial effects of immediate treatment compared with delayed initiation of treatment.
Details
- Title: Subtitle
- IM interferon beta-1a delays definite multiple sclerosis 5 years after a first demyelinating event
- Creators
- R Philip KinkelCraig KollmanPaul O'ConnorThomas Jock MurrayJack SimonDouglas ArnoldRohit BakshiBianca Weinstock-GutmanStaley BrodJoanna CooperPierre DuquetteEric EggenbergerWarren FeltonRobert FoxMark FreedmanSteven GalettaAndrew GoodmanJoseph GuarnacciaStanley HashimotoSteven HorowitzJeffrey JaverbaumLloyd KasperMichael KaufmanLloyd KersonMichelle MassKottil RammohanMerrell ReissLoren RolakJohn RoseThomas ScottJohn SelhorstRobert ShinCraig SmithWilliam StuartStephen ThurstonMichael WallCHAMPIONS Study Group
- Resource Type
- Journal article
- Publication Details
- Neurology, Vol.66(5), pp.678-684
- DOI
- 10.1212/01.wnl.0000200778.65597.ae
- PMID
- 16436649
- ISSN
- 0028-3878
- eISSN
- 1526-632X
- Language
- English
- Date published
- 03/14/2006
- Academic Unit
- Neurology; Ophthalmology and Visual Sciences
- Record Identifier
- 9984187240802771
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